{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:12Z","timestamp":1777418832519,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Aldosterone antagonists are the mainstay of therapy in patients with hypertension due to primary aldosteronism. However, in our experience, these patients are sometimes placed on angiotensin-converting enzyme (ACE) inhibitors in accordance with guidelines applying to the general hypertensive population. We believe this practice is inappropriate because of the inability of ACE inhibitors to lower blood pressure in patients with low renin levels. Furthermore, pleiotropic effects of ACE inhibitors are unlikely to provide significant benefits in the absence of blood pressure reduction. Therefore, ACE inhibitors should be discouraged for the majority of patients with primary aldosteronism, even in the face of renal or cardiac disease.<\/jats:p>","DOI":"10.1345\/aph.1h456","type":"journal-article","created":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T22:08:18Z","timestamp":1166566098000},"page":"129-132","source":"Crossref","is-referenced-by-count":7,"title":["Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Hypertension Due to Primary Aldosteronism: A Case for Exclusion"],"prefix":"10.1177","volume":"41","author":[{"given":"Carolyn D","family":"Bubbar","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F","family":"Blackburn","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merne P","family":"Wilson","sequence":"additional","affiliation":[{"name":"Ambulatory Hypertension Clinic, Royal University Hospital, Saskatoon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W","family":"Wilson","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Saskatchewan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"bibr1-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.073"},{"key":"bibr2-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"bibr3-aph.1H456","unstructured":"Canadian Hypertension Education Program. 2006 Canadian Hypertension Education Program recommendations. www.hypertension.ca\/index2.html (accessed 2006 May 20)."},{"key":"bibr4-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.167587"},{"key":"bibr5-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134791.68010.FA"},{"key":"bibr6-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0279"},{"key":"bibr7-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.5.563"},{"key":"bibr8-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392507"},{"key":"bibr9-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06102-9"},{"key":"bibr10-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00070.x"},{"key":"bibr11-aph.1H456","first-page":"33","volume":"18","author":"Wilson TR","year":"2002","journal-title":"Perspect Cardiol"},{"key":"bibr12-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2217"},{"key":"bibr13-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1080\/08037050600772615"},{"key":"bibr14-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.385"},{"key":"bibr15-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67814-2"},{"key":"bibr16-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1982.38"},{"key":"bibr17-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.22.2638"},{"key":"bibr18-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.2.128"},{"key":"bibr19-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06178-5"},{"key":"bibr20-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05012-0"},{"key":"bibr21-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16451-9"},{"key":"bibr22-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"bibr23-aph.1H456","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040135"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1H456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1H456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:22Z","timestamp":1777374502000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1H456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1345\/aph.1H456"],"URL":"https:\/\/doi.org\/10.1345\/aph.1h456","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}