{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:35:07Z","timestamp":1784194507282,"version":"3.55.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the literature examining prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>Articles were identified via MEDLINE\/PubMed\/EMBASE (1966\u2013March 2007) using the following key terms: vaccination, immunization, diphtheria\u2013tetanus toxoids\u2013whole pertussis (DTwP), diphtheria tetan us\u2013toxoid. whole pertussis, diphtheria-tetanus toxoids\u2013acellular pertussis (DTaP), acellular pertussis, Haemophilus influenzae type B, inactivated poliovirus, pneumococcal 7-valent conjugate, measles, mumps, rubella, meningococcal C-conjugate, varicella zoster, hepatitis B, influenza, pneumococcal polysaccharide, adverse reactions, analgesics, antipyretics, acetaminophen, ibuprofen, infant, and child.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>No limitations were placed on article selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Five articles examining the effects of prophylactic acetaminophen or ibuprofen for adverse effects associated with either DTaP or DTwP vaccine were retrieved. In one randomized controlled trial of children aged 4\u20136 years given DTaP, no effect of prophylactic acetaminophen 15 mg\/kg\/dose, up to 450 mg, or ibuprofen 10 mg\/kg\/dose, up to 300 mg, was found on the incidence of fever, redness, pain, swelling, or itching. In 3 randomized studies of DTwP, either acetaminophen 10\u201315 mg\/kg\/dose or ibuprofen 20 mg\/kg\/24 hours, given in 3 equal doses before or at the time of immunization and every 4\u20138 hours thereafter for 12 or more hours, reduced fever, pain, fussiness, and local redness in infants 2\u20137 months of age compared with placebo. Results were not duplicated in older infants\/children. No studies investigated use of prophylactic acetaminophen or ibuprofen for any other vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Use of prophylactic acetaminophen and ibuprofen may reduce the incidence of adverse reactions in young infants receiving DTwP vaccine; however, DTwP has been replaced with DTaP, and no benefits have been demonstrated for this vaccine when evaluated in children aged 4\u20136 years, or with any other vaccine currently in use. Thus, neither drug can be recommended prophylactically to prevent vaccine-associated adverse reactions. Individuals at high risk for seizures may, however, warrant special consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1h647","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T13:35:28Z","timestamp":1179927328000},"page":"1227-1232","source":"Crossref","is-referenced-by-count":29,"title":["Acetaminophen and Ibuprofen for Prevention of Adverse Reactions Associated with Childhood Immunization"],"prefix":"10.1177","volume":"41","author":[{"given":"Jennifer","family":"Manley","sequence":"first","affiliation":[{"name":"Graduate Department of Pharmaceutical Sciences, University of Toronto, and Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Taddio","sequence":"additional","affiliation":[{"name":"Department of Child Health Evaluative Sciences, Department of Pharmacy, The Hospital for Sick Children, Leslie Dan Faculty of Pharmacy, University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"bibr1-aph.1H647","volume-title":"Canadian immunization guide","year":"2002","edition":"6"},{"key":"bibr2-aph.1H647","volume-title":"Supplementary information on vaccine safety: part 2. 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Daptacel IM vaccine injection (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed)","year":"2003"},{"issue":"13","key":"bibr6-aph.1H647","first-page":"1","volume":"49","author":"Centers for Disease Control and Prevention.","year":"2000","journal-title":"MMWR Morbid Mortal Wkly Rep"},{"key":"bibr7-aph.1H647","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80270-0"},{"key":"bibr8-aph.1H647","doi-asserted-by":"publisher","DOI":"10.1542\/peds.88.2.401"},{"key":"bibr9-aph.1H647","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800718"},{"key":"bibr10-aph.1H647","volume-title":"Acel\u2013Immune (Purogenated diphtheria toxoid, Purogenated tetanus toxoid and acellular pertussis vaccine absorbed)","author":"Package insert.","year":"1996"},{"key":"bibr11-aph.1H647","unstructured":"Taketomo CK, Hodding JH, Kraus DM. Pediatric dosage handbook. 13th ed. 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