{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:18:36Z","timestamp":1791202716459,"version":"4.2.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The development of clinical pharmacy activities in most European countries is underway; however, data on these activities are still poorly reported. Multicenter studies are necessary to standardize and demonstrate the value of clinical pharmacy activities in these countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To document clinical pharmacists' daily routine interventions (Pls) to identify trends of intervention, drugs, and situations most frequently associated with drug-related problems (DRPs) and to estimate physicians' acceptance of PI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective study of Pls was conducted in 6 French hospitals. The sample consisted of 300 randomized Pls par hospital, recorded during the medication order validation process when a DRP was identified. We recorded patients' demographic characteristics, drugs involved, wards, DRP description, pharmacists' recommendations, and whether or not the recommendations were accepted by the physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 38, 626 medication orders were analyzed by 28 clinical pharmacists, leading to 1800 Pls (4.66 Pls per 100 medication orders). Of the 1800 Pls, 25.9% targeted psychotropic drugs, 15.9% targeted antithrombotic drugs. 15.5% targeted digestive and metabolic drugs, and 15.0% targeted cardiovascular drugs. The most commonly identified DRPs were nonconformity to guidelines or contraindication (21.3%), followed by improper administration (20.6%), supratherapeutic dose (19.2%), and drug interaction (12.6%). Nearly half (42.2%) of the pharmacists' recommendations were related to drug choice (drug switch 22.2%, drug discontinuation 16.3%, addition of a new drug 3.7%) followed by dose adjustment (23.8%), optimization of administration (21, 9%; change of administration route 10.3%, administration modalities 11.6%), and need for drug monitoring (12.2%). The rate of physicians' acceptance was 73.4% (15.3% refusals, 11.3% not assessable).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In French hospitals, pharmacists contribute to preventing DRPs during medication order validation. This study suggests that a few types of drugs and errors constitute a substantial proportion of Pls. Knowledge of the most frequent DRPs could significantly increase the efficiency of clinical Pls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1l045","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T20:45:57Z","timestamp":1213735557000},"page":"1095-1103","source":"Crossref","is-referenced-by-count":104,"title":["Assessment of Clinical Pharmacists' Interventions in French Hospitals: Results of a Multicenter Study"],"prefix":"10.1177","volume":"42","author":[{"given":"Pierrick","family":"Bedouch","sequence":"first","affiliation":[{"name":"Clinical Pharmacist, P\u00f4le pharmacie, Centre Hospitalier-Universitaire de Grenoble & Laboratoire ThEMAS TIMC UMR CNRS 5525, Universit\u00e9 Joseph Fourier, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Charpiat","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Conort","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie, H\u00f4pital Cochin, Assistance Publique des H\u00f4pitaux de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Rose","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie-CRIM, H\u00f4tel-Dieu, Centre Hospitalier-Universitaire de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Escofier","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie, Centre Hospitalier de Mayenne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Juste","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie, Centre Hospitalier Auban-Mo\u00ebt, Epernay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Roubille","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Service Pharmacie, Centre Hospitalier Lucien Hussel, Vienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Allenet","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist and Assistant Professor in Clinical Pharmacy, P\u00f4le pharmacie, Centre Hospitalier-Universitaire de Grenoble & Laboratoire ThEMAS TIMC UMR CNRS 5525, Universit\u00e9 Joseph Fourier"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"bibr1-aph.1L045","volume-title":"To err is human: building a safer health system","author":"Kohn LT","year":"1999"},{"key":"bibr2-aph.1L045","volume-title":"Preventing medication errors: quality chasm series","author":"Aspden 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