{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:40:33Z","timestamp":1777419633140,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report on adverse reactions associated with amiodarone and propylthiouracil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY<\/jats:title>\n                    <jats:p>A 64-year-old female with atrial fibrillation and nodular goiter progressed to overt thyrotoxicosis after receiving therapy with amiodarone 200 mg\/day for less than 12 weeks. Thyroid scan revealed a hyperfunctioning nodule in the left lobe, while immunologic studies were negative for both thyroid peroxidase and thyroglobulin antibodies. The thyroid-stimulating hormone (TSH) receptor antibody level was transiently elevated. Propylthiouracil 100 mg 3 times\/day was started after the withdrawal of amiodarone, but the patient developed severe generalized skin rash, fever, and leukocytosis after 4 weeks. Thyroidectomy was performed, and histopathology was compatible with type 1 amiodarone-induced thyrotoxicosis (AIT) associated with toxic nodular goiter. An objective causality assessment revealed that thyrotoxicosis was probably related to use of amiodarone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Amiodarone is an antiarrhythmic agent that may cause thyroid dysfunction. Differentiating between the 2 types of AIT is important for implementation of the correct therapeutic strategy. The transient elevation of TSH receptor antibodies in AIT complicated the diagnosis. As a rare subtype, type 1 AIT by nodular goiter may be associated with early AIT. Initiating thyroid function monitoring within 3 months of amiodarone therapy should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Type 1 AIT caused by nodular goiter is rarely reported. Amiodarone should be avoided in such patients and subtotal thyroidectomy to remove the toxic nodule may be the treatment of choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1l347","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T21:58:32Z","timestamp":1230069512000},"page":"134-138","source":"Crossref","is-referenced-by-count":4,"title":["Amiodarone-Induced Thyrotoxicosis in a Patient with Autonomously Functioning Nodular Goiter"],"prefix":"10.1177","volume":"43","author":[{"given":"Yi-Lin","family":"Liang","sequence":"first","affiliation":[{"name":"Yi-Lin Liang MD, Fellow, Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Shih-Ming Huang MD, Professor of Surgery, College of Medicine, National Cheng Kung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ling","family":"Peng","sequence":"additional","affiliation":[{"name":"Shu-Ling Peng MD, Consultant, Department of Pathology, National Cheng Kung University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hwa","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Shu-Hwa Hsiao BSc (Pharm), Clinical Pharmacist, Department of Pharmacy, National Cheng Kung University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Chang","family":"Hung","sequence":"additional","affiliation":[{"name":"Hao-Chang Hung MD, Consultant, Department of Internal Medicine, National Cheng Kung University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horng-Yih","family":"Ou","sequence":"additional","affiliation":[{"name":"Horng-Yih Ou MD, Assistant Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung 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