{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:13:22Z","timestamp":1777418002274,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2009,2]]},"abstract":"\n Objective:<\/jats:title>\n To report a case of serum sickness\u2013like reaction (SSLR) possibly induced by efalizumab, a recombinant humanized immunoglobulin G1 \u03ba isotype monoclonal antibody approved for treatment of moderate-to-severe plaque psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Case Summary:<\/jats:title>\n A 37-year-old woman with plaque psoriasis who had been treated with efalizumab for 2 months developed a fever, erythematous rash, and progressive joint swelling and pain that required hospitalization. An exhaustive workup for infectious and rheumatologic causes of the patient's symptoms was negative. Given the relative temporal relationship between efalizumab therapy and the patient's signs and symptoms, a diagnosis of serum sickness was made. Systemic corticosteroids were initiated, which resulted in rapid resolution of the patient's signs and symptoms. Use of an objective causality assessment suggests that the patient's SSLR was possibly related to efalizumab.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Like many therapeutic monoclonal antibodies, efalizumab is associated with several adverse events, including allergic reactions. SSLR, a nonimmediate hypersensitivity syndrome, can occur with a variety of drugs including monoclonal antibodies. However, a MEDLINE search (1964\u2013July 2008) identified only one other possible case of SSLR related to efalizumab.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Clinicians using efalizumab should be aware of this possible adverse reaction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1l495","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:04:00Z","timestamp":1233702240000},"page":"383-386","source":"Crossref","is-referenced-by-count":13,"title":["Serum Sickness\u2013Like Reaction Associated with Efalizumab"],"prefix":"10.1177","volume":"43","author":[{"given":"Sadia","family":"Ashraf-Benson","sequence":"first","affiliation":[{"name":"DO, Post-Graduate Year-2 Medical Resident, Iowa Methodist Medical Center (IMMC), Des Moines, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey C","family":"Wall","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinical Pharmacist, IMMC; Associate Professor of Pharmacy Practice, College of Pharmacy and Health Sciences, Drake University, Des Moines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Veach","sequence":"additional","affiliation":[{"name":"Infectious Diseases Physician, IMMC; Clinical Associate Professor, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"bibr1-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2006.12.002"},{"key":"bibr2-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.028"},{"key":"bibr3-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1080\/09546630601121086"},{"key":"bibr4-aph.1L495","unstructured":"Product information. Raptiva (efalizumab). www.gene.com\/gene\/products\/information\/immunological\/raptiva\/insert.jsp (accessed 2008 Sept 5)."},{"key":"bibr5-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr6-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115663"},{"key":"bibr7-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1016\/0045-9380(91)90065-S"},{"key":"bibr8-aph.1L495","first-page":"307","volume-title":"Patterson's allergic diseases","author":"Ditto AM","year":"2002"},{"key":"bibr9-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411293112204"},{"key":"bibr10-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.011"},{"key":"bibr11-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02786.x"},{"key":"bibr12-aph.1L495","first-page":"430","volume":"34","author":"Todd DJ","year":"2007","journal-title":"J Rheumatol"},{"key":"bibr13-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2005.01.033"},{"key":"bibr14-aph.1L495","first-page":"305","volume":"3","author":"Krishnan RS","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"bibr15-aph.1L495","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.2.197"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1L495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1L495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:18Z","timestamp":1777374378000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1L495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1345\/aph.1L495"],"URL":"https:\/\/doi.org\/10.1345\/aph.1l495","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}