{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:16:47Z","timestamp":1777418207908,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Implantable cardioverter defibrillators (ICDs) are indicated for both primary and secondary prevention of sudden cardiac arrest, \u03b2-Blockers are also indicated in most patients who have an indication for an ICD; however, their use in this population is not well described. Some clinicians may be unaware of the recommendation for \u03b2-blockers in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To explore \u03b2-blocker use among ICD recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Adults who received their first ICD at Duke Hospital between July 1999 and July 2004 for primary or secondary prevention of sudden cardiac arrest were identified. Using hospital data, \u03b2-blocker use was determined at time of discharge, and characteristics of users were compared with those of nonusers. Continued use of \u03b2-blockers after ICD implant was explored in the subset of patients included in the Duke Databank for Cardiovascular Disease (DDCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study cohort comprised 804 patients, 652 (81%) with ICD for secondary prevention of sudden cardiac arrest and 152 (19%) for primary prevention. The median age was 65 years and 75% of the patients were men. A total of 544 (68%) received a \u03b2-blocker at time of ICD implant. There were no substantial changes in the proportion of patients with \u03b2-blocker use from 1999 through 2004, overall or within the primary or secondary prevention groups. However, \u03b2-blocker use was higher in the secondary prevention group than in the primary prevention group (69% vs 60%; p = 0.02). A higher proportion of \u03b2-blocker users versus nonusers had ischemic heart disease (82% vs 68%; p &lt; 0.0001), heart failure (84% vs 71%; p &lt; 0.0001), previous myocardial infraction (51 % vs 44%; p = 0.05), and ventricular arrhythmias (82% vs 76%; p = 0.04). Of the 425 patients included in the DDCD, only 241 (57%) were receiving \u03b2-blockers at time of implant and during clinical follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Lower than optimal use of \u03b2-blockers suggests the need for new methods of including evidence-based medications in clinical practice, especially for complex patients for whom numerous clinical practice guidelines may apply.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1m140","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T22:29:21Z","timestamp":1246400961000},"page":"1189-1196","source":"Crossref","is-referenced-by-count":2,"title":["Use of \u03b2-Blockers in Patients with an Implantable Cardioverter Defibrillator"],"prefix":"10.1177","volume":"43","author":[{"given":"Nancy M Allen","family":"LaPointe","sequence":"first","affiliation":[{"name":"School of Medicine, Duke University, Duke Clinical Research Institute, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A","family":"Stafford","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute\u2013Outcomes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Pappas","sequence":"additional","affiliation":[{"name":"Biostatistician, INC Research, Raleigh, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana M","family":"Al-Khatib","sequence":"additional","affiliation":[{"name":"School of Medicine, Duke University, Duke Clinical Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J","family":"Anstrom","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke University, Duke Clinical Research 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