{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:42:08Z","timestamp":1791042128907,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the weight-loss effects of pramlintide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature search was conducted in MEDLINE (1950\u2013October week 4, 2009), International Pharmaceutical Abstracts (1970\u2013October 2009), and Evidence Based Medicine Database (1991\u20132009 week 44) to identify relevant publications. Key words searched included pramlintide, weight loss, obesity, and overweight. Additional data sources were obtained through a bibliographic review of selected articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection\/Data Extraction:<\/jats:title>\n                    <jats:p>All studies conducted on humans and published in English that examined the effects of pramlintide on body weight as a primary or secondary endpoint were selected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Pramlintide is a human amylin analog approved by the Food and Drug Administration for use in conjunction with insulin therapy in patients with type 1 or 2 diabetes. In addition to its glucoregulatory actions, pramlintide has been shown to increase satiety and, therefore, decrease calorie Intake via a central mechanism. Several studies show that this translates into statistically significant weight loss in overweight or obese patients with type 1 or 2 diabetes; patients with type 1 diabetes lost up to 1.7 kg over 1 year with pramlintide 60 \u03bcg 3 times daily, while patients with type 2 diabetes experienced a placebo-subtracted weight loss of up to 3.7 kg after 16 weeks of pramlintide 120\u2013240 \u03bcg administered 3 times daily. Preliminary trials assessing the use of pramlintide for weight loss in obese patients without diabetes have demonstrated weight loss of up to 8 kg after 1 year. In all studies, the drug was generally well tolerated, with nausea being the most commonly reported adverse effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Based on preliminary evidence, pramlintide facilitates modest weight loss in obese or overweight patients with and without diabetes. However, current trials were limited by inconsistent study design, dosing, and patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1m210","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T22:24:35Z","timestamp":1266445475000},"page":"538-545","source":"Crossref","is-referenced-by-count":46,"title":["The Role of Pramlintide for Weight Loss"],"prefix":"10.1177","volume":"44","author":[{"given":"Kaelen C","family":"Dunican","sequence":"first","affiliation":[{"name":"Massachusetts College of Pharmacy and Health Sciences-Worcester\/Manchester, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M","family":"Adams","sequence":"additional","affiliation":[{"name":"Rite Aid Pharmacy, Milford, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia R","family":"Desilets","sequence":"additional","affiliation":[{"name":"Massachusetts College of Pharmacy and Health Sciences-Worcester\/Manchester"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"bibr1-aph.1M210","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1549"},{"key":"bibr2-aph.1M210","volume-title":"Obesity among adults in the United States\u2014no change since 2003\u20132004. NCHS data brief no 1","author":"Ogden CL","year":"2007"},{"key":"bibr3-aph.1M210","unstructured":"National Institutes of Health, National Heart, Lung and Blood Institute, North American Association for the Study of Obesity. The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. 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