{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:29:22Z","timestamp":1790749762957,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the clinical utility of diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine ([DTaP-IPV]; Kinrix) and diphtheria and tetanus toxoids and acellular pertussis adsorbed, Inactivated poliovirus and Haemophilus b conjugate (tetanus toxoid conjugate) vaccine ([DTaP-IPV\/Hib]; Pentacel) in the schedule for pediatric immunizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>PubMed was searched (1966\u2013April 2009) using the key words Kinrix and Pentacel. Subject headings included vaccines, combined; diphtheria-tetanus-pertussis vaccine; diphtheria-tetanus-acellular pertussis vaccines; poliovirus vaccine, inactivated; and Haemophilus influenzae type b polysaccharide vaccinetetanus toxin conjugate. The search was limited to English-language publications involving humans. Product labeling was obtained from GlaxoSmithKline and Sanofi Pasteur. The Centers for Disease Control and Prevention (CDC) Web site was searched for relevant recommendations published June 2008\u2013October 2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection And Data Extraction:<\/jats:title>\n                    <jats:p>Phase 2 and 3 clinical trials evaluating immunogenicity and safety of DTaP-IPV and DTaP-IPV\/Hib were reviewed. Published trials were supplemented with abstracts, review articles, manufacturer product labeling, and CDC recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>DTaP-IPV is immunogenic compared to its component vaccines, with no effect of concomitantly administered measles, mumps, and rubella vaccine. Although injection site pain has occurred more with the combination vaccine, its use would reduce by 1 the number of injections given when a child is 4\u20136 years old. DTaP-IPV\/Hib is immunogenic and safe compared to separate vaccines. Immunogenicity to 7-valent pneumococcal conjugate vaccine and hepatitis B (HepB) vaccine is not affected by concomitant administration. DTaP-IPV\/Hib decreases injections by up to 7 when given at 2, 4, 6, and 15\u201318 months of age. It fits into the schedule more easily than DTaP-HepB-IPV (Pediarix), the other DTaP-containing combination vaccine indicated for the primary infant series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>DTaP-IPV and DTaP-IPV\/Hib combination vaccines are immunogenic and safe when given to infants and children. They reduce the number of required injections. Combination vaccines are encouraged to promote timely vaccination and complete immunization schedules.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1m468","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T22:00:37Z","timestamp":1267567237000},"page":"515-523","source":"Crossref","is-referenced-by-count":17,"title":["New Combination Vaccines: DTaP-IPV (Kinrix) and DTaP-IPV\/Hib (Pentacel)"],"prefix":"10.1177","volume":"44","author":[{"given":"Tracy L","family":"Johns","sequence":"first","affiliation":[{"name":"Family Medicine Residency, University of South Florida, Morton Plant Mease Health Care;, Department of Family Medicine, College of Medicine, University of South Florida, Clearwater, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E","family":"Hutter","sequence":"additional","affiliation":[{"name":"Family Medicine Residency, University of South Florida, Morton Plant Mease Health Care;, Department of Family Medicine, College of Medicine, University of South Florida; Administrator, Clinical Research, Morton Plant Mease Health Care, BayCare Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"bibr1-aph.1M468","first-page":"1","volume":"48","year":"1999","journal-title":"MMWR Recomm Rep"},{"key":"bibr2-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815dd80f"},{"key":"bibr3-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31805d7f17"},{"key":"bibr4-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000222413.47344.23"},{"key":"bibr5-aph.1M468","first-page":"506","volume":"13","author":"Happe LE","year":"2007","journal-title":"Am J Manag Care"},{"key":"bibr6-aph.1M468","unstructured":"Haemophilus influenzae infections. In: Pickering LK, Baker CJ, Long SS, McMillan JA eds. Red book: 2006 report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2006: 310\u20138."},{"key":"bibr7-aph.1M468","volume-title":"Kinrix (diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine)","author":"Product information.","year":"2009"},{"key":"bibr8-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.7.9.1309"},{"key":"bibr9-aph.1M468","volume-title":"Pentacel (diphtheria and tetanus toxoid and acellular pertussis adsorbed, inactivated poliovirus and Haemophilus b conjugate (tetanus toxoid conjugate) vaccine)","author":"Product information.","year":"2008"},{"key":"bibr10-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.4.6.793"},{"key":"bibr11-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.001"},{"key":"bibr12-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.017"},{"key":"bibr13-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181616180"},{"key":"bibr14-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1080\/00365540410020884"},{"key":"bibr15-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.12.009"},{"key":"bibr16-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00241-7"},{"key":"bibr17-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3317"},{"key":"bibr18-aph.1M468","doi-asserted-by":"publisher","DOI":"10.4161\/hv.1.5.2079"},{"key":"bibr19-aph.1M468","unstructured":"Edwards KTP, Wang L, Safety and immunogenicity of DTaP-IPV\/\/PRP-T (Pentacel) coadministered with pneumococcal conjugate vaccine (Prevnar) at 2, 4, and 6 months of age (abstract 984). Presented at: 43rd Annual Meeting, Infectious Disease Society of America, 2005."},{"key":"bibr20-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.11.021"},{"key":"bibr21-aph.1M468","unstructured":"Food and Drug Administration. Center for Biologics Evaluation and Research. Guidance for industry for the evaluation of combination vaccines for preventable diseases: production, testing and clincal studies. April 1997. www.fda.gov\/downloads\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/Vaccines\/UCM175909.pdf (accessed 2009 Nov 3)."},{"key":"bibr22-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04356-5"},{"key":"bibr23-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.1.25"},{"key":"bibr24-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200108000-00010"},{"key":"bibr25-aph.1M468","first-page":"1008","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr26-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.666"},{"key":"bibr27-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602083340602"},{"key":"bibr28-aph.1M468","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06508-2"},{"key":"bibr29-aph.1M468","unstructured":"Centers for Disease Control and Prevention. ACIP provisional recommendations for the use of combination vaccines: August 2009. www.cdc.gov\/vaccines\/recs\/provisional\/default.htm (accessed 2009 Oct 19)."},{"key":"bibr30-aph.1M468","volume-title":"Guidance on the use of Pentacel and Pediarix","author":"Centers for Disease Control and Prevention.","year":"2008"},{"key":"bibr31-aph.1M468","first-page":"673","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr32-aph.1M468","first-page":"1079","volume":"57","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr33-aph.1M468","first-page":"1078","volume":"57","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr34-aph.1M468","volume-title":"Pediarix (diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis b (recombinant), and inactivated poliovirus vaccine combined)","author":"Product information.","year":"2009"},{"key":"bibr35-aph.1M468","volume-title":"Epidemiology and prevention of vaccine-preventable diseases","author":"Atkinson W","year":"2009","edition":"11"},{"key":"bibr36-aph.1M468","first-page":"829","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"51","key":"bibr37-aph.1M468","first-page":"M468","volume":"57","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1M468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1M468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:26Z","timestamp":1777374446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1M468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1345\/aph.1M468"],"URL":"https:\/\/doi.org\/10.1345\/aph.1m468","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}