{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:03:49Z","timestamp":1792728229269,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T00:00:00Z","timestamp":1266883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe cerebral spinal fluid (CSF) penetration of tigecycline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary:<\/jats:title>\n                    <jats:p>A 38-year-old woman experienced a right internal carotid artery dissection and right anterior and middle cerebral artery strokes due to unknown causes and subsequently developed vasogenic edema requiring right hemicraniectomy. Her postoperative course was complicated by multiple infections, and she developed multidrug, carbapenem-resistant Acinetobacter baumannii cerebritis. She was treated with a prolonged course of multiple antibiotics, including 18 days of therapy with tigecycline. Time-paired serum and CSF samples were obtained, and tigecycline concentrations were analyzed by high-performance liquid chromatography. We report serial, steady-state, serum, and CSF concentrations of tigecycline when administered in the Food and Drug Administration-approved dose of 50 mg every 12 hours. CSF concentrations remained relatively stable, suggesting that tigecycline did not accumulate in the CSF, at least in our patient. Tigecycline concentrations in the CSF were between 0.035 and 0.048 mg\/L, while corresponding serum concentrations were 0.097\u20130.566 mg\/L. The calculated tigecycline penetration ratio in this patient ranged from 0% to 52%, depending on the calculation methodology utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Concentrations, regardless of sample timing relative to dose, remained relatively stable in the CSF of our patient. The pharmacodynamic profile of tigecycline is not completely elucidated; however, it is presumed that the drug must be at the site of infection for efficacy. Our patient never obtained tigecycline concentrations in excess of the minimum inhibitory concentration for A. baumannii in either the serum or the CSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our patient experienced low CSF tigecycline concentrations and failed to achieve a clinical response while on therapy. CSF drug disposition of tigecycline requires further systematic study to fully elucidate the pharmacokinetic profile. Reduced CSF concentrations urge caution in the treatment of cerebritis with standard dosing of tigecycline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1m480","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T22:18:50Z","timestamp":1266963530000},"page":"582-586","source":"Crossref","is-referenced-by-count":41,"title":["Cerebral Spinal Fluid Penetration of Tigecycline in a Patient with Acinetobacter baumannii Cerebritis"],"prefix":"10.1177","volume":"44","author":[{"given":"Leslie","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL; now, Oncology Specialty Resident, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Levasseur","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Northwestern Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H","family":"Scheetz","sequence":"additional","affiliation":[{"name":"Midwestern University Chicago College of Pharmacy; Infectious Diseases Pharmacist, Northwestern Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,23]]},"reference":[{"key":"bibr1-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070741"},{"key":"bibr2-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70055-6"},{"key":"bibr3-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1086\/432803"},{"key":"bibr4-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01877-07"},{"key":"bibr5-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01099-06"},{"key":"bibr6-aph.1M480","volume-title":"Tygacil (tigecycline)","author":"Product information.","year":"2009"},{"key":"bibr7-aph.1M480","volume-title":"Clinical and Laboratory Standards Institute performance standards for antimicrobial susceptibility testing; nineteenth informational supplement. CLSI document M100-S19 (ISBN 1-56238-690-5)","year":"2009"},{"key":"bibr8-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3903-3909.2005"},{"key":"bibr9-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(04)00745-7"},{"key":"bibr10-aph.1M480","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464010-00005"},{"key":"bibr11-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62479-3"},{"key":"bibr12-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.2.347"},{"key":"bibr13-aph.1M480","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-4-482"},{"key":"bibr14-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl403"},{"key":"bibr15-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e318181fa38"},{"key":"bibr16-aph.1M480","unstructured":"Clinical pharmacology and biopharmaceutics review(s). Wyeth Pharmaceuticals. New Drug Application no. 21\u2013821. Center for Drug Evaluation and Research, 2005. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2005\/21-821_Tygacil_BioPharmr.pdf (accessed 2009 Jul 29)."},{"key":"bibr17-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1177\/875512250702300604"},{"key":"bibr18-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.943-949.2000"},{"key":"bibr19-aph.1M480","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.51451"},{"key":"bibr20-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.21"},{"key":"bibr21-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1086\/313757"},{"key":"bibr22-aph.1M480","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01678-08"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1M480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1M480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:26Z","timestamp":1777374446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1M480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,23]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1345\/aph.1M480"],"URL":"https:\/\/doi.org\/10.1345\/aph.1m480","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,23]]}}}