{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:19:03Z","timestamp":1777418343732,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review relevant literature supporting the use of \u03b2-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, digoxin, aldosterone antagonists, and vasodilators in the management of heart failure in an elderly patient population aged \u226565 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>PubMed, EMBASE, and MEDLINE searches (January 1960\u2013April 2010) were utilized to identify primary literature using the key terms heart failure, treatment, and elderly. Additionally, reference citations from publications identified were utilized, as well as the American College of Cardiology\/American Heart Association (ACC\/AHA) Guidelines for the Diagnosis and Management of Chronic Heart Failure in the Adult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Primary and tertiary literature, including subgroup analyses, published in English and relating to the use of pharmacotherapy in the treatment of systolic heart failure in the elderly was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>The aging of the US population is creating a higher prevalence of systolic heart failure in the elderly. Most clinical trials have established the mortality and morbidity benefit of pharmacotherapy in heart failure in nonelderly patients; however, the current ACC\/AHA guidelines do not clearly delineate this benefit in persons \u226565 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clinical trial data, based on limited numbers of individuals aged \u226565 years, suggest that use of \u03b2-blockers, ACE inhibitors, ARBs, aldosterone antagonists, and vasodilators (hydralazine\/nitrates) have similar mortality benefit to that observed in younger patients. As supported in the ACC\/AHA guidelines, these agents should be prescribed with clinical judgment to all elderly patients, with close monitoring for adverse events. Future clinical trials with greater inclusion of patients \u226565 years will help to elucidate the magnitude of benefits of optimal pharmacotherapy on mortality and morbidity rates in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1p128","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T23:50:22Z","timestamp":1284508222000},"page":"1604-1614","source":"Crossref","is-referenced-by-count":11,"title":["Cardiology: Treatment of Systolic Heart Failure in the Elderly: An Evidence-Based Review"],"prefix":"10.1177","volume":"44","author":[{"given":"Sally A","family":"Arif","sequence":"first","affiliation":[{"name":"Midwestern University, Chicago College of Pharmacy, Downers Grove, IL; Clinical Pharmacist Specialist-Cardiology, Department of Pharmacy, Rush University Medical Center, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl A","family":"Mergenhagen","sequence":"additional","affiliation":[{"name":"Veterans Affairs Western NY Healthcare System, Buffalo, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"O Diaz Del Carpio","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ho","sequence":"additional","affiliation":[{"name":"James J Peters Veterans Affairs Medical Center; now, Assistant Professor of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY; Clinical Pharmacist Specialist-Ambulatory Care, Department of Pharmacy, Department of Veterans Affairs, New York Harbor Healthcare System"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,9,14]]},"reference":[{"key":"bibr1-aph.1P128","unstructured":"SultzH, YoungK. 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