{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:45:28Z","timestamp":1787852728488,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the literature examining the use of gabapentin for treatment of hot flashes during natural or surgically Induced menopause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature search was conducted via PubMed, MEDLINE, and International Pharmaceutical Abstracts (1948-November 2010) using the search terms gabapentin, hot flashes, and menopause. Literature was limited to English-language, human studies. Additional material was identified by reviewing reference citations of the articles retrieved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Studies with data describing gabapentin for hot flash management during natural or surgically induced menopause were included. Any studies including women with a history of breast cancer were excluded. Four studies met the inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Gabapentin significantly decreased hot flash frequency and hot flash composite scores by 45-71% from baseline in the 4 trials included in this review. In 2 of the trials, gabapentin was comparable to hormone replacement therapy (71 % vs 72%, respectively, p = 0.63) in decreasing hot flash composite scores at the end of 12 weeks and in decreasing hot flash frequency at the end of 8 weeks (58.9% vs 70.1 %, p &gt; 0.05). In all trials, the most common adverse effects with gabapentin were somnolence\/drowsiness, unsteadiness, and dizziness. These adverse effects were most pronounced during the first 1-2 weeks of therapy, but resolved and were similar to those reported with placebo by week 4. These trials were short (&lt;12 weeks) and had small sample sizes; however, their results appear to show that gabapentin is safe and effective for short-term treatment of hot flashes in women who have entered menopause either naturally or surgically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Gabapentin 600-2400 mg\/day in divided doses may be a viable option for treating hot flashes in menopausal women who do not want to use hormone replacement therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1p366","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T22:53:36Z","timestamp":1298415216000},"page":"388-394","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Use of Gabapentin for the Management of Natural or Surgical Menopausal Hot Flashes"],"prefix":"10.1177","volume":"45","author":[{"given":"Laura P","family":"Hayes","sequence":"first","affiliation":[{"name":"Auburn University, Tuscaloosa, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana G","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi W","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"bibr1-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000108177.85442.71"},{"key":"bibr2-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869479"},{"key":"bibr3-aph.1P366","doi-asserted-by":"publisher","DOI":"10.4065\/77.11.1207"},{"key":"bibr4-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"bibr5-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2161"},{"key":"bibr6-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200310030-00007"},{"key":"bibr7-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.07.007"},{"key":"bibr8-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000010676.54597.22"},{"key":"bibr9-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67215-7"},{"key":"bibr10-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1080\/13697130902736921"},{"key":"bibr11-aph.1P366","first-page":"337","volume":"101","author":"Guttuso T","year":"2003","journal-title":"Obstet Gynecol"},{"key":"bibr12-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000222383.43913.ed"},{"key":"bibr13-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3180dca175"},{"key":"bibr14-aph.1P366","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903511539"},{"issue":"4","key":"bibr15-aph.1P366","first-page":"CD002978","author":"MacLennan AH","year":"2004","journal-title":"Cochrane Syst Rev"},{"key":"bibr16-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008382706068"},{"key":"bibr17-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.081"},{"key":"bibr18-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.10.007"},{"key":"bibr19-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03403-6"},{"key":"bibr20-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1188\/02.ONF.33-40"},{"key":"bibr21-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-1-124"},{"key":"bibr22-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl478"},{"key":"bibr23-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.7324"},{"key":"bibr24-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000147840.06947.46"},{"key":"bibr25-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1002\/da.20085"},{"key":"bibr26-aph.1P366","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-12-200612190-00003"},{"key":"bibr27-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.4296"},{"key":"bibr28-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-200026394"},{"key":"bibr29-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849885"},{"key":"bibr30-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(02)00349-3"},{"key":"bibr31-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(02)00350-X"},{"key":"bibr32-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1080\/09513590400020922"},{"key":"bibr33-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849914"},{"key":"bibr34-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2007.04.009"},{"key":"bibr35-aph.1P366","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2004.10.003"},{"key":"bibr36-aph.1P366","first-page":"1","volume":"4","author":"Lethaby AE","year":"2007","journal-title":"Cochrane Syst Rev"},{"key":"bibr37-aph.1P366","volume-title":"Neurontin (gabapentin)","author":"Package insert","year":"2010"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1P366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1P366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:27Z","timestamp":1777374507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1P366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,22]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1345\/aph.1P366"],"URL":"https:\/\/doi.org\/10.1345\/aph.1p366","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,22]]}}}