{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:12:15Z","timestamp":1778659935781,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T00:00:00Z","timestamp":1308614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ezetimibe, a first-in-its-class inhibitor of cholesterol absorption, is an effective agent for combined use with statins to achieve low-density lipoprotein cholesterol (LDL-C) goals. Ezetimibe in combination with simvastatin as a single-tablet formulation has proven to be highly effective in reducing serum LDL-C through the dual inhibition of cholesterol absorption and biosynthesis. The effect of time of administration on efficacy of this combination therapy has not been evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the effects of morning versus evening administration of ezetimibe\/simvastatin on serum cholesterol levels of patients with primary hypercholesterolemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this multicenter, open-label, randomized, 2-sequence, 2-period crossover study, patients with primary hypercholesterolemia randomly received ezetimibe\/simvastatin 10 mg\/20 mg once daily, either in the morning (within 1 hour of breakfast) or in the evening (within 1 hour of dinner) for 6 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data on 171 patients (87 in the morning administration group and 84 in the evening administration group) were analyzed. A significant reduction (p \u2264 0.001) in the total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL-C, apo-lipoprotein B, and high-sensitivity C-reactive protein (hs-CRP) from baseline was achieved after each treatment. Noninferiority of morning administration versus evening administration was shown in the percentage reduction of the LDL-C level from baseline (difference, \u20131.62%; 90% CI \u20134.94 to 1.70). No significant difference was found between groups with respect to the percentage of changes in other lipid parameters from baseline. Furthermore, there was no significant difference in the percentage of change in hs-CRP as an antiinflammatory marker between the morning and evening administration groups. The frequency of adverse events was similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Morning administration of ezetimibe\/simvastatin 10 mg\/20 mg is noninferior to evening administration with respect to LDL-C\u2013lowering ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1p511","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:48:20Z","timestamp":1308703700000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Effects of Morning Versus Evening Administration of Ezetimibe\/Simvastatin on Serum Cholesterol in Patients with Primary Hypercholesterolemia"],"prefix":"10.1177","volume":"45","author":[{"given":"Hyung Sik","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Sun General Hospital, Cardiovascular Center, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sun General Hospital, Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sun General Hospital, Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hun","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Sun General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ee","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Sun General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sun General Hospital; Cardiology Physician, Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Gi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sun General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University, Daejeon; Cardiology Physician, Department of Internal Medicine, Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Soo","family":"Hyon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Soonchunhyang University; Cardiology Physician, Cardiovascular Institution, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"bibr1-aph.1P511","first-page":"1383","volume":"344","author":"Scandinavian Simvastatin Survival Study Group.","year":"1994","journal-title":"Lancet"},{"key":"bibr2-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511163332001"},{"key":"bibr3-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03267-8"},{"key":"bibr4-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705187"},{"key":"bibr5-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093131"},{"key":"bibr6-aph.1P511","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200303010-00007"},{"key":"bibr7-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01633.x"},{"key":"bibr8-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X100131"},{"key":"bibr9-aph.1P511","first-page":"344","volume":"3","author":"Kalogirou M","year":"2007","journal-title":"Arch Med Sci"},{"key":"bibr10-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.01.062"},{"key":"bibr11-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"bibr12-aph.1P511","volume-title":"Zocor (simvastatin) tablets","author":"Package insert.","year":"2009"},{"key":"bibr13-aph.1P511","volume-title":"Mevacor (lovastatin) tablets","author":"Package insert.","year":"2009"},{"key":"bibr14-aph.1P511","volume-title":"Lescol (fluvastatin) tablets","author":"Package insert.","year":"2009"},{"key":"bibr15-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.9.3037"},{"key":"bibr16-aph.1P511","volume-title":"Lipitor (atorvastatin calcium) tablets","author":"Package insert.","year":"2009"},{"key":"bibr17-aph.1P511","volume-title":"Pravachol (pravastatin) tablets","author":"Package insert.","year":"2009"},{"key":"bibr18-aph.1P511","volume-title":"Crestor (rosuvastatin) tablets","author":"Package insert.","year":"2009"},{"key":"bibr19-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"bibr20-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(00)00162-4"},{"key":"bibr21-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02614-0"},{"key":"bibr22-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.10.001"},{"key":"bibr23-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990815)18:15<1903::AID-SIM188>3.0.CO;2-F"},{"key":"bibr24-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1201\/9781420002027"},{"key":"bibr25-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1201\/9780203911341"},{"key":"bibr26-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.2.237"},{"key":"bibr27-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"bibr28-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116763.91992.F1"},{"key":"bibr29-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649939"},{"key":"bibr30-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442601"},{"key":"bibr31-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02774-1"},{"key":"bibr32-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018744.58460.62"},{"issue":"2","key":"bibr33-aph.1P511","first-page":"S36","volume":"8","author":"Stein EA","year":"2002","journal-title":"Am J Manag Care"},{"key":"bibr34-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7418.788"},{"key":"bibr35-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.185"},{"key":"bibr36-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(90)90114-X"},{"key":"bibr37-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01688.x"},{"key":"bibr38-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1996.tb04224.x"},{"key":"bibr39-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1159\/000093200"},{"key":"bibr40-aph.1P511","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.08.012"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1P511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1P511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:47Z","timestamp":1777374527000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1P511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,21]]},"references-count":40,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1345\/aph.1P511"],"URL":"https:\/\/doi.org\/10.1345\/aph.1p511","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,21]]}}}