{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:28:05Z","timestamp":1777418885620,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of lasofoxifene (CP-336156), a selective estrogen receptor modulator (SERM) that is not approved for use in the US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>Literature was accessed through the MEDLINE and EMBASE databases (1985-June 2010) using the terms lasofoxifene and selective estrogen receptor modulators. Reference lists from retrieved articles were also manually reviewed. The Food and Drug Administration and Pfizer provided additional information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>All clinical trials evaluating lasofoxifene were included in (his review. In addition, all articles evaluating the pharmacology, pharmacokinetics, and safety of lasofoxifene in humans were reviewed. DATA SYNTHESIS: Lasofoxifene is a third-generation SERM with markedly higher in vitro and in vivo potency and oral bioavailability than other SERMs. The drug has produced significant improvements in bone density and biochemical markers of bone turnover in preclinical studies and in Phase 2 and 3 clinical trials. In these trials, lasofoxifene has shown a favorable safety profile, with adverse events including hot (lushes, leg cramps, and increased vaginal moisture. One 2-year major comparative study in postmenopausal women determined that lasofoxifene and raloxifene were equally effective at increasing total hip bone mineral density (BMD), while lasofoxifene had a significantly greater effect on lumbar spine BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Osteoporosis is a significant health problem. While the results of further clinical trials are needed to define the risks and benefits of treatment, particularly relating to fractures, lasofoxifene may prove to be an effective and well-tolerated therapeutic option for the prevention of bone toss in postmenopausal women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1p604","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T23:20:23Z","timestamp":1302045623000},"page":"499-509","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Lasofoxifene: Selective Estrogen Receptor Modulator for the Prevention and Treatment of Postmenopausal Osteoporosis"],"prefix":"10.1177","volume":"45","author":[{"given":"Gregory M","family":"Peterson","sequence":"first","affiliation":[{"name":"Unit for Medication Outcomes Research and Education, School of Pharmacy, University of Tasmania, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Naunton","sequence":"additional","affiliation":[{"name":"Charles Darwin University, Northern Territory, Australia; Faculty of Health, University of Canberra, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette K","family":"Tichelaar","sequence":"additional","affiliation":[{"name":"University of Groningen, Groningen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Gennari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,5]]},"reference":[{"key":"bibr1-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68891-0"},{"key":"bibr2-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39050.597350.47"},{"key":"bibr3-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0325"},{"key":"bibr4-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C246"},{"key":"bibr5-aph.1P604","volume-title":"Bone health and osteoporosis: a report of the Surgeon General","author":"Department of Health and Human Services.","year":"2004"},{"key":"bibr6-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08657-9"},{"key":"bibr7-aph.1P604","first-page":"294","volume":"7","author":"Hogson S","year":"2001","journal-title":"Endocr Pract"},{"key":"bibr8-aph.1P604","volume-title":"Working with patients to prevent, treat, and manage osteoporosis: a curriculum guide for the health professions","author":"Gold D","year":"2001","edition":"3"},{"key":"bibr9-aph.1P604","first-page":"1067","volume":"6","author":"Gennari L","year":"2005","journal-title":"Curr Opin Invest Drugs"},{"key":"bibr10-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008243430801"},{"key":"bibr11-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030808"},{"key":"bibr12-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.7.605"},{"key":"bibr13-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17558-2"},{"key":"bibr14-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1290.037"},{"key":"bibr15-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2006.09.008"},{"key":"bibr16-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.12.1603"},{"key":"bibr17-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1385\/BMM:3:2:125"},{"key":"bibr18-aph.1P604","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(04)80057-2"},{"key":"bibr19-aph.1P604","volume-title":"Management of osteoporosis. 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