{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:28:57Z","timestamp":1777418937672,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Low hemoglobin (Hb) concentrations before lower limb joint replacement are associated with the need for blood transfusions and increased mortality. To optimize preoperative Hb, blood conservation protocols often recommend oral iron supplements, even in nonanemic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To investigate the impact of ferrous sulfate on the change in Hb prior to hip or knee arthroplasty and evaluate the effect of oral iron on hematocrit, mean corpuscular volume (MCV), ferritin, and transferrin saturation, as well as its tolerability and treatment adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective, observational cohort study of adults with Hb concentrations between 10 and 15 g\/dL who received iron supplementation prior to hip or knee arthroplasty. Systemic inflammatory diseases, vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      or folate deficiency, and current use of iron supplements, intravenous iron, or erythropoietin were exclusion criteria. All participants were prescribed ferrous sulfate 300 mg 3 times daily for a minimum of 3 weeks. Complete blood cell counts and iron studies were performed before therapy and surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Eighty-seven patients with a mean (SD) Hb of 13.47 (0.84) g\/dL were included in the study. Preoperative Hb decreased after treatment with iron (-0.14 [0.53] g\/dL, p = 0.015). Hematocrit also declined (-0.6% [1.8%], p = 0.002), whereas ferritin increased (25.8 [38.6] ng\/mL, p &lt; 0.001). No significant change was seen in MCV and transferrin saturation. The most common adverse effects were constipation (33.3%), heartburn (13.8%), and abdominal pain (12.6%). The adherence rate was 67.1%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Oral ferrous sulfate supplementation is not an effective method to increase preoperative Hb in patients scheduled for hip or knee arthroplasty, and its use is associated with adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1p757","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T22:37:29Z","timestamp":1307745449000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Oral Ferrous Sulfate Does Not Increase Preoperative Hemoglobin in Patients Scheduled for Hip or Knee Arthroplasty"],"prefix":"10.1177","volume":"45","author":[{"given":"Kim","family":"Lachance","sequence":"first","affiliation":[{"name":"Kim Lachance BPharm, PhD Candidate, Pharmacist, Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Savoie","sequence":"additional","affiliation":[{"name":"Michel Savoie BPharm MSc, Pharmacist, Pharmacy Coordinator, Faculty of Pharmacy, University of Montreal, Maisonneuve-Rosemont Hospital, Montreal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryse","family":"Bernard","sequence":"additional","affiliation":[{"name":"Maryse Bernard BPharm MSc, Pharmacist, Campbellton Regional Hospital, Campbellton, NB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Rochon","sequence":"additional","affiliation":[{"name":"St\u00e9phanie Rochon BPharm MSc, Pharmacist, Sainte-Agathe-des-Monts Hospital, Quebec"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Fafard","sequence":"additional","affiliation":[{"name":"Jos\u00e9e Fafard MD, Internist, Assistant Clinical Professor, University of Montreal, Maisonneuve-Rosemont Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Robitaille","sequence":"additional","affiliation":[{"name":"Robert Robitaille PhD, Clinical Biochemist, Maisonneuve-Rosemont Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal-Andr\u00e9","family":"Vendittoli","sequence":"additional","affiliation":[{"name":"Pascal-Andr\u00e9 Vendittoli MD MSc FRCS, Orthopedic Surgeon, Associate Professor of Surgery, University of Montreal, Maisonneuve-Rosemont Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"L\u00e9vesque","sequence":"additional","affiliation":[{"name":"Sylvie L\u00e9vesque MSc, Biostatistician, Montreal Heart Institute Coordinating Center, Montreal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"de Denus","sequence":"additional","affiliation":[{"name":"Simon de Denus BPharm PhD, Pharmacist, Assistant Professor, Beaulieu-Saucier Chair in Pharmacogenomics, Faculty of Pharmacy, University of Montreal, Montreal Heart Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,10]]},"reference":[{"key":"bibr1-aph.1P757","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-8-1"},{"key":"bibr2-aph.1P757","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2008.06.006"},{"key":"bibr3-aph.1P757","volume-title":"(CJRR) 2008-2009 Annual Report","author":"Hip and Knee Replacements in Canada\u2014Canadian Joint Replacement 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