{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:30:14Z","timestamp":1777419014916,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,9]]},"abstract":"\n Objective:<\/jats:title>\n To evaluate the use of budesonide for the treatment of autoimmune hepatitis (AIH).<\/jats:p>\n <\/jats:sec>\n \n Data Sources:<\/jats:title>\n Literature was accessed through PubMed\/MEDLINE (1966-June 2011) and Web of Science (1965-June 2011) using the terms autoimmune hepatitis and budesonide. Literature was limited to English-language publications. In addition, references from publications identified were reviewed.<\/jats:p>\n <\/jats:sec>\n \n Study Selection And Data Extraction:<\/jats:title>\n All articles in English identified from the data sources were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Data Synthesis:<\/jats:title>\n The initial treatment of choice for A1H is prednisone alone or with azathioprine. However, a significant number of patients do not respond adequately or have adverse reactions to this regimen; therefore, alternative treatments are required. Budesonide is an orally administered synthetic corticosteroid with high affinity for the glucocorticoid receptor that undergoes extensive first-pass metabolism. It has Food and Drug Administration-approved labeling for the treatment and maintenance of remission of mild-to-moderate Crohn disease involving the ileum and\/or ascending colon. One prospective, active-controlled study of budesonide in the treatment of AIH was identified, as well as 5 small open-label studies and 1 retrospective chart review. Budesonide appears to have efficacy in the treatment of AIH, including in patients intolerant to standard therapy with prednisone alone or with azathioprine, with a reduced incidence of corticosteroid-related adverse reactions. However, in patients with AIH and cirrhosis, the efficacy of budesonide may be reduced and the incidence of corticosteroid-related adverse reactions may be increased.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Budesonide may be an additional treatment option for patients with AIH but without cirrhosis who are intolerant to standard therapy with prednisone or prednisone with azathioprine.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1q244","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T22:52:10Z","timestamp":1314744730000},"page":"1144-1150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Budesonide for the Treatment of Autoimmune Hepatitis"],"prefix":"10.1177","volume":"45","author":[{"given":"Kenneth R","family":"Snider","sequence":"first","affiliation":[{"name":"Internal Medicine, Virginia Commonwealth University Health System\/Medical College of Virginia Hospitals, Richmond, VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa G","family":"Potter","sequence":"additional","affiliation":[{"name":"Internal Medicine, Virginia Commonwealth University Health System\/Medical College of Virginia 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