{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:48Z","timestamp":1777418868387,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2011,12]]},"abstract":"\n Objective:<\/jats:title>\n To determine whether clinical trial data support the use of nitroglycerin for prevention of postmenopausal osteoporosis.<\/jats:p>\n <\/jats:sec>\n \n Data Sources:<\/jats:title>\n A literature search using MEDLINE (1966-September 2011) and EMBASE (1973-September 2011) was conducted using the search terms nitroglycerin, bone mineral density, fracture, and osteoporosis. References of identified articles were reviewed for additional citations.<\/jats:p>\n <\/jats:sec>\n \n Study Selection and Data Extraction:<\/jats:title>\n All English-language articles related to the use of nitroglycerin ointment in postmenopausal women were reviewed.<\/jats:p>\n <\/jats:sec>\n \n Data Synthesis:<\/jats:title>\n Four observational studies reported significant improvements in bone mineral density of postmenopausal women with the use of nitrates. One pilot study and 2 prospective, randomized, placebo-controlled clinical trials reported conflicting results regarding the efficacy of nitroglycerin ointment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Clinical data do not support use of nitroglycerin for this indication; its potential is limited at this time by inconclusive efficacy and a high Incidence of headache. Further well-designed clinical trials demonstrating efficacy and safety of nitroglycerin ointment for prevention of postmenopausal osteoporosis are needed before this medication can be recommended for routine use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1q410","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:20:31Z","timestamp":1318983631000},"page":"1566-1570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nitroglycerin Ointment for the Prevention of Postmenopausal Osteoporosis"],"prefix":"10.1177","volume":"45","author":[{"given":"Robert D","family":"Beckett","sequence":"first","affiliation":[{"name":"Drug Information Specialist, Manchester College School of Pharmacy, Fort Wayne, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy Heck","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Purdue University College of Pharmacy, West Lafayette, IN; Drug Information Specialist, Indiana University Health, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"bibr1-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.11.022"},{"key":"bibr2-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100771"},{"key":"bibr3-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181c617e6"},{"key":"bibr4-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.066"},{"key":"bibr5-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.6.1119"},{"key":"bibr6-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00125-7"},{"key":"bibr7-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00005-1"},{"key":"bibr8-aph.1Q410","volume-title":"Nitro-BID (nitroglycerin ointment)","author":"Package insert.","year":"2009"},{"key":"bibr9-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2342"},{"key":"bibr10-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060804"},{"key":"bibr11-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.11.1755"},{"key":"bibr12-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0727-7"},{"key":"bibr13-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.11.2240"},{"key":"bibr14-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2225"},{"key":"bibr15-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.176"},{"key":"bibr16-aph.1Q410","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.117"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1Q410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1Q410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:16Z","timestamp":1777374496000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1Q410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,18]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1345\/aph.1Q410"],"URL":"https:\/\/doi.org\/10.1345\/aph.1q410","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,18]]}}}