{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:43:44Z","timestamp":1784832224345,"version":"3.55.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a possible interaction between warfarin and ceftaroline, resulting in hemarthrosis, and provide readers with an understanding of mechanisms of interaction between cephalosporins and warfarin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>Ceftaroline was prescribed for an 85-year-old female with a therapeutic international normalized ratio (INR) hospitalized for the treatment of cellulitis. She was subsequently readmitted with shoulder pain and a supratherapeutic INR. The patient was diagnosed with hemarthrosis, presumably related to elevated INR. Evaluation using the drug interaction probability scale for warfarin and ceftaroline yielded a score consistent with a possible or probable interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Cephalosporins may interact with warfarin through a variety of mechanisms, including potentiation of hypoprothrombinemia related to certain side chain groups, inhibition of P-glycoprotein, or alteration of gastrointestinal flora. All mechanisms reported in the medical literature as of April 2012 are briefly examined, but the latter is the most reasonable mechanism for a ceftaroline interaction with warfarin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Health care providers should consider closely monitoring patients receiving antibiotics with activity against Enterobacteriaceae and warfarin, even if no direct mechanism of interaction has been reported. Further research regarding a ceftaroline-warfarin interaction is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1q771","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T15:46:47Z","timestamp":1341416807000},"page":"e19-e19","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Hemarthrosis in a Patient on Warfarin Receiving Ceftaroline: A Case Report and Brief Review of Cephalosporin Interactions with Warfarin"],"prefix":"10.1177","volume":"46","author":[{"given":"Nicole M","family":"Bohm","sequence":"first","affiliation":[{"name":"Nicole M Bohm PharmD, Assistant Professor, Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Crosby","sequence":"additional","affiliation":[{"name":"Brittany Crosby, PharmD Student 2012, College of Pharmacy, Medical University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"bibr1-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00060-4"},{"key":"bibr2-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0555-z"},{"key":"bibr3-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"bibr4-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H423"},{"key":"bibr5-aph.1Q771","first-page":"531","volume":"17","author":"Conly J","year":"1994","journal-title":"Clin Invest Med"},{"key":"bibr6-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03090150019004"},{"key":"bibr7-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C243"},{"key":"bibr8-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03824.x"},{"key":"bibr9-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01716-09"},{"key":"bibr10-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir147"},{"key":"bibr11-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199903\/04)8:2<81::AID-PDS411>3.0.CO;2-G"},{"key":"bibr12-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.6.1108"},{"key":"bibr13-aph.1Q771","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.12.2369"},{"key":"bibr14-aph.1Q771","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0022-3565(25)23944-1","volume":"235","author":"Kerremans AL","year":"1985","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr15-aph.1Q771","volume-title":"Package insert. 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