{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:04:53Z","timestamp":1781103893210,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Extended-interval aminoglycoside dosing is increasingly used in neonates; however, guidance on how to monitor concentrations and adjust dosages accordingly is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To prospectively validate the use of a 22-hour gentamicin concentration dosing table for the individualization of extended-interval dosing in the neonatal population by examining the peak and trough concentrations achieved through its use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A prospective observational study was carried out on gentamicin concentrations achieved using a 22-hour post\u2013first-dose gentamicin concentration dosing table for determining dosing intervals in neonates. Neonates (N = 104) in the first week of life, gestational age 23 weeks to full term, in level II and III neonatal intensive care units were included. Neonates were given gentamicin 5 mg\/kg intravenously; a table using 22-hour post-first-dose gentamicin concentrations was then used to individualize dosing intervals. Pre- and post-serum gentamicin concentrations on the dosing interval indicated were measured with the second or third doses and used to calculate the peak and trough concentrations achieved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Use of the 22-hour post-first-dose gentamicin concentration dosing table resulted in dosing intervals that provided appropriate peak (mean 10.55 mg\/L) and trough (mean 0.75 mg\/L) concentrations (with second or third doses) in all neonates. All patients had trough concentrations less than 2 mg\/L, and 73% had a trough concentration less than 1 mg\/L. No peak concentrations were less than 5 mg\/L, 82% of patients had a peak concentration from 5 to 12 mg\/L, and the remaining 18% had concentrations from 12.1 to 16 mg\/L. Peak and trough concentrations were similar across all gestational ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Use of a 22-hour post-first-dose gentamicin concentration dosing table to individualize extended-interval gentamicin dosages in neonates resulted in appropriate peak and trough concentrations in all neonates studied. Use of this table will result in appropriate extended-interval aminoglycoside dosages in neonates early in treatment, using a single serum concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1r029","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T11:45:18Z","timestamp":1340797518000},"page":"935-942","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Validation of a Dosage Individualization Table for Extended-Interval Gentamicin in Neonates"],"prefix":"10.1177","volume":"46","author":[{"given":"Deonne","family":"Dersch-Mills","sequence":"first","affiliation":[{"name":"Deonne Dersch-Mills PharmD ACPR, Pharmacy Clinical Practice Leader, Pediatrics & Neonatology, Alberta Health Services, Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Akierman","sequence":"additional","affiliation":[{"name":"Albert Akierman MD, Emeritus Associate Professor, University of Calgary, Alberta; Consultant Neonatologist, Department of Pediatrics, Division of Neonatology, Alberta Health Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belal","family":"Alshaikh","sequence":"additional","affiliation":[{"name":"Belal Alshaikh MD, Neonatal Fellow, Alberta Health Services, MSc Student, Clinical Epidemiology, University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Kamran Yusuf MD FAAP, Assistant Professor, University of Calgary; Department of Pediatrics, Division of Neonatology, Alberta Health Services"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"bibr1-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.594"},{"key":"bibr2-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00057-6"},{"key":"bibr3-aph.1R029","first-page":"47","volume":"7","author":"Craig WA","year":"1995","journal-title":"J Chemother"},{"key":"bibr4-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.e111"},{"key":"bibr5-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.056317"},{"key":"bibr6-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005091.pub2"},{"key":"bibr7-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-820515"},{"key":"bibr8-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199812000-00017"},{"key":"bibr9-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70127-6"},{"key":"bibr10-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210704"},{"key":"bibr11-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.032284"},{"key":"bibr12-aph.1R029","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp040532"},{"key":"bibr13-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210996"},{"key":"bibr14-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200203000-00014"},{"key":"bibr15-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36836"},{"key":"bibr16-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13436"},{"key":"bibr17-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.11.1297"},{"key":"bibr18-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012221801816"},{"key":"bibr19-aph.1R029","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100114"},{"key":"bibr20-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.123595"},{"key":"bibr21-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.01.013"},{"key":"bibr22-aph.1R029","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948020-00001"},{"key":"bibr23-aph.1R029","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-6-8"},{"key":"bibr24-aph.1R029","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070314"},{"key":"bibr25-aph.1R029","unstructured":"Young TE, Mangum B, eds. 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