{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:41:06Z","timestamp":1790833266804,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of foodborne botulism and subsequent use of the investigational heptavalent botulism antitoxin (H-BAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 60-year-old man was hospitalized with blurred vision, diplopia, and dysarthria. On hospital day 2, the patient was transferred to the intensive care unit for progressive fatigable weakness with ptosis, dysphagia, dysarthria, and nausea. Secondary to worsening respiratory distress, the patient was intubated and placed on a ventilator. The patient could open his eyes only with assistance but still had normal strength in all extremities. H-BAT was administered 48 hours after presentation for possible botulism. The patient then revealed that he consumed home-canned corn several days prior to admission. On hospital day 8, botulinum neurotoxin was confirmed in the patient's serum and the home-canned corn. The patient slowly regained muscle strength and was discharged to a long-term acute care facility on hospital day 22.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Foodborne botulism is caused by a neurotoxin from Clostridium botulinum and usually occurs after the consumption of improperly prepared home-canned food. Botulism is characterized by symmetrical descending paralysis that may progress to respiratory arrest. The standard confirmatory test for botulism is a mouse bioassay to prove the presence of botulinum neurotoxin. Outside of supportive care, the treatment options for botulism are limited. Individuals with botulism often require intensive care unit monitoring and potentially ventilatory support. H-BAT, the only treatment available for botulism in patients older than 1 year, is a purified and despeciated equine-derived immunoglobulin active against all known botulinum neurotoxins. H-BAT's despeciation significantly reduces the risk of hypersensitivity reactions, anaphylaxis, and serum sickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In a confirmed case of foodborne botulism treated with H-BAT, the patient tolerated H-BAT and did not develop any hypersensitivity reactions or serum sickness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1r646","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T23:55:58Z","timestamp":1359503758000},"page":"e12-e12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Foodborne Botulism Treated with Heptavalent Botulism Antitoxin"],"prefix":"10.1177","volume":"47","author":[{"given":"Stanley E","family":"Hill","sequence":"first","affiliation":[{"name":"Stanley E Hill PharmD, Critical Care Pharmacy Specialist, Department of Inpatient Pharmacy, Long Beach Memorial Medical Center, Long Beach, CA; Assistant Clinical Professor\u2014WOS, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla; Assistant Clinical Professor\u2014WOS, Department of Clinical Pharmacy, University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Raza Iqbal MD, Infectious Disease Physician, Long Beach Memorial Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L","family":"Cadiz","sequence":"additional","affiliation":[{"name":"Christine L Cadiz MA PharmD, PGY-1 Pharmacy Resident, University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Le","sequence":"additional","affiliation":[{"name":"Jennifer Le PharmD MAS FCCP BCPS-ID, Associate Professor of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego; Faculty-in-Residence, Department of Inpatient Pharmacy, Long Beach Memorial Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"bibr1-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1086\/444507"},{"key":"bibr2-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"bibr3-aph.1R646","first-page":"337","volume-title":"Medical aspects of biological warfare","author":"Dembek ZF","year":"2008"},{"key":"bibr4-aph.1R646","volume-title":"Handbook for epidemiologists, clinicians, and laboratory workers","author":"Botulism in the United States, 1899\u20131996","year":"1998"},{"key":"bibr5-aph.1R646","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-3-199808010-00011"},{"key":"bibr6-aph.1R646","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.030745"},{"key":"bibr7-aph.1R646","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-4-442"},{"key":"bibr8-aph.1R646","first-page":"1454","volume":"60","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr9-aph.1R646","doi-asserted-by":"publisher","DOI":"10.4161\/hv.9420"},{"key":"bibr10-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/731604"},{"key":"bibr11-aph.1R646","unstructured":"Dynport Vaccine Company. Press release page. CSC's DynPort Vaccine Company releases results for Phase 2 botulinum vaccine clinical trial. http:\/\/www.csc.com\/dvc\/press_releases\/77621-csc_s_dynport_vaccine_company_releases_results_for_phase_2_botulinum_vaccine_clinical_trial (accessed 2012 Jul 6)."},{"key":"bibr12-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.18.1.13"},{"key":"bibr13-aph.1R646","first-page":"379","volume":"32","author":"Davis LE","year":"1992","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"bibr14-aph.1R646","first-page":"601","volume":"31","author":"Dock M","year":"2002","journal-title":"Presse Med"},{"key":"bibr15-aph.1R646","first-page":"473","volume":"48","author":"Ball AP","year":"1979","journal-title":"Q J Med"},{"key":"bibr16-aph.1R646","first-page":"299","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr17-aph.1R646","unstructured":"Centers for Disease Control and Prevention. IND Protocol: Use of NP-018 heptavalent equine-based botulinum antitoxin (H-BAT) after exposure to\n                      Clostridium botulinum\n                      toxin or other closely-related botulinum toxin-producing\n                      Clostridia\n                      species due to a naturally occurring outbreak or isolated incident. BB-IND 6750, August 16, 2010: version 7.0."},{"key":"bibr18-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90988-4"},{"key":"bibr19-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.3.660"},{"key":"bibr20-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.2.337"},{"key":"bibr21-aph.1R646","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90469-6"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1R646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1R646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1R646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:12:37Z","timestamp":1777374757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1R646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1345\/aph.1R646"],"URL":"https:\/\/doi.org\/10.1345\/aph.1r646","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}