{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:48:08Z","timestamp":1777420088630,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe a case in which a linezolid desensitization protocol was successfully used for a polymicrobial surgical wound infection in a patient with multiple drug hypersensitivity reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY<\/jats:title>\n                    <jats:p>A 24-year-old woman with vocal cord dysfunction requiring tracheostomy was admitted for a surgical wound infection following a tracheostomy fistula closure procedure. The patient reported multiple antibiotic allergies including penicillins (rash), sulfonamides (rash), vancomycin (anaphylaxis), azithromycin (rash), cephalosporins (anaphylaxis), levofloxacin (unspecified), clindamycin (unspecified), and carbapenems (unspecified). Gram stain of the purulent wound drainage demonstrated mixed gram-negative and gram-positive flora, and bacterial cultures were overgrown with Proteus mirabilis, which precluded identification of other pathogens. Following failed test doses of linezolid, tigecycline, and daptomycin, all of which resulted in hypersensitivity reactions, a 16-step linezolid desensitization protocol was developed and successfully implemented without adverse reactions. The patient completed a 2-week course of antibiotic therapy that included linezolid upon finishing the desensitization protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Linezolid is useful in treating complicated and uncomplicated skin and soft tissue infections caused by gram-positive bacteria. With precautions, including premedication, a monitored nursing unit, and immediate availability of an emergency anaphylaxis kit, drug desensitization allows patients the ability to safely use medications to which they may have an immediate hypersensitivity reaction. Minimal data exist on linezolid desensitization protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Linezolid desensitization can be a viable option in patients requiring antimicrobial therapy for complicated gram-positive skin infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1s033","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:53:07Z","timestamp":1369788787000},"page":"e30-e30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Linezolid Desensitization for a Patient with Multiple Medication Hypersensitivity Reactions"],"prefix":"10.1177","volume":"47","author":[{"given":"Autumn D","family":"Bagwell","sequence":"first","affiliation":[{"name":"Autumn D Bagwell, PharmD Student, McWhorter School of Pharmacy, Samford University, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna L","family":"Stollings","sequence":"additional","affiliation":[{"name":"Joanna L Stollings PharmD BCPS, Clinical Pharmacy Specialist, Department of Pharmaceutical Services, Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie D","family":"White","sequence":"additional","affiliation":[{"name":"Katie D White MD, Clinical Fellow, Division of Infectious Diseases, Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olajumoke O","family":"Fadugba","sequence":"additional","affiliation":[{"name":"Olajumoke O Fadugba MD, Clinical Fellow, Department of Allergy and Immunology, Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane J","family":"Choi","sequence":"additional","affiliation":[{"name":"Jane J Choi MD, Assistant Professor of Medicine, Division of Allergy and Immunology, Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"bibr1-aph.1S033","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(09)60009-8"},{"key":"bibr2-aph.1S033","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.4.563"},{"key":"bibr3-aph.1S033","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1599-1602.2006"},{"key":"bibr4-aph.1S033","first-page":"201","volume":"55","author":"Chegini S","year":"2008","journal-title":"Drug Allergy"},{"key":"bibr5-aph.1S033","doi-asserted-by":"publisher","DOI":"10.1086\/345744"},{"key":"bibr6-aph.1S033","first-page":"87","volume":"5","author":"Ager S","year":"2012","journal-title":"Infect Drug Resist"},{"key":"bibr7-aph.1S033","volume-title":"Lexi-Drugs 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