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In particular, it was wished to determine whether such quantitative assessment techniques can detect minor degrees of impairment at a stage in the putative disease process before apraxia has become clinically obvious. A total of 23 individuals with MCI and 75 healthy controls were assessed on two 3\u2010item sequential movement tasks involving either meaningful or meaningless actions. A traditional rating scale assessment of gesture\u2010to\u2010command was also administered. MCI patients took significantly longer than control subjects to complete the sequential movement tasks despite unimpaired performance on the traditional gesture production tasks. Furthermore, retrospective analyses revealed that, at the group level, only MCI patients who subsequently proceeded to a clinical diagnosis of AD were significantly slower than controls at the initial assessment. These findings provide the first evidence that the neuropsychological deficits associated with MCI may extend to the domain of praxic functions. Consequently, this work contributes to the growing literature questioning the clinical usefulness of the concept of MCI and the appropriateness of current diagnostic criteria for distinguishing this condition from mild AD.<\/jats:p>","DOI":"10.1348\/174866407x209943","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T19:32:39Z","timestamp":1187897559000},"page":"237-257","source":"Crossref","is-referenced-by-count":19,"title":["A novel technique for the quantitative assessment of apraxic deficits: Application to individuals with mild cognitive impairment"],"prefix":"10.1111","volume":"1","author":[{"given":"Sebastian J.","family":"Crutch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin N.","family":"Rossor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth K.","family":"Warrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(13)80292-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08256-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.411"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700020468"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11920-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638408401233"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1462"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199903)14:2<276::AID-MDS1013>3.0.CO;2-U"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/026432900380427"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/713756780"},{"key":"e_1_2_9_13_1","first-page":"73","article-title":"Age\u2010associated memory impairment: Diagnostic criteria and treatment strategies","volume":"21","author":"Crook T.","year":"1987","journal-title":"International Journal of Neurology"},{"key":"e_1_2_9_14_1","unstructured":"Crutch S. 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