{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:58:34Z","timestamp":1791111514492,"version":"4.1.0"},"reference-count":68,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2\u00a0weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome.<\/jats:p>","DOI":"10.1352\/1944-7558-115.5.433","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T13:49:44Z","timestamp":1286286584000},"page":"433-443","source":"Crossref","is-referenced-by-count":87,"title":["Side Effects of Minocycline Treatment in Patients With Fragile X Syndrome and Exploration of Outcome Measures"],"prefix":"10.1080","volume":"115","author":[{"given":"Agustini","family":"Utari","sequence":"first","affiliation":[{"name":"M.I.N.D. Institute, University of California at Davis Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerasak","family":"Chonchaiya","sequence":"first","affiliation":[{"name":"M.I.N.D. Institute, University of California at Davis Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Rivera","sequence":"first","affiliation":[{"name":"M.I.N.D. Institute, University of California at Davis Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schneider","sequence":"first","affiliation":[{"name":"M.I.N.D. Institute, University of California at Davis Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi J.","family":"Hagerman","sequence":"first","affiliation":[{"name":"M.I.N.D. Institute, University of California at Davis Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultana M. H.","family":"Faradz","sequence":"first","affiliation":[{"name":"Diponegoro University, Center for Biomedical Research (Semarang, Central Java, Indonesia)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna M.","family":"Ethell","sequence":"first","affiliation":[{"name":"Biomedical Sciences and Neuroscience Program, University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danh V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, University of California Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","reference":[{"key":"2020060218481045700_i1944-7558-115-5-433-Abe1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2169\/internalmedicine.42.48","article-title":"Drug-induced hepatitis with autoimmune features during minocycline therapy.","volume":"42","author":"Abe","year":"2003","journal-title":"Internal Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Akin1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1542\/peds.101.5.926","article-title":"Minocycline-induced lupus in adolescent.","volume":"101","author":"Akin","year":"1998","journal-title":"Pediatrics"},{"key":"2020060218481045700_i1944-7558-115-5-433-American1","volume-title":"Diagnostic and statistical manual of mental disorders (4th ed., Text Rev.)","author":"American Psychiatric Association","year":"2000"},{"key":"2020060218481045700_i1944-7558-115-5-433-Ang1","first-page":"229","article-title":"Pseudotumor cerebri secondary to minocycline intake.","volume":"15","author":"Ang","year":"2002","journal-title":"Journal of the American Board of Family Practice"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bantubungi1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nbd.2004.09.017","article-title":"Minocycline in phenotypic models of Huntington's disease.","volume":"18","author":"Bantubungi","year":"2005","journal-title":"Neurobiology of Disease"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bassell1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2008.10.004","article-title":"Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function.","volume":"60","author":"Bassell","year":"2008","journal-title":"Neuron"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bear1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/sj.npp.1301610","article-title":"Fragile X: Translation in action.","volume":"33","author":"Bear","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bear2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation.","volume":"27","author":"Bear","year":"2004","journal-title":"Trends in Neurosciences"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bergles1","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.18-19-07709.1998","article-title":"Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus.","volume":"18","author":"Bergles","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"2020060218481045700_i1944-7558-115-5-433-BerryKravis1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/jmg.2008.063701","article-title":"A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.","volume":"46","author":"Berry-Kravis","year":"2009","journal-title":"Journal of Medical Genetics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bilousova1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model.","volume":"46","author":"Bilousova","year":"2009","journal-title":"Journal of Medical Genetics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Bowles1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1708-8240.1998.tb00355.x","article-title":"Protection againts minocycline pigment formation by ascorbic acid (vitamin C).","volume":"10","author":"Bowles","year":"1998","journal-title":"Journal of Esthetic Dentistry"},{"key":"2020060218481045700_i1944-7558-115-5-433-Cascio1","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1128\/AAC.48.7.2739-2741.2004","article-title":"No findings of dental defects in children treated with minocycline.","volume":"48","author":"Cascio","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"2020060218481045700_i1944-7558-115-5-433-Choi1","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1038\/sj.npp.1301377","article-title":"Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models.","volume":"32","author":"Choi","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"2020060218481045700_i1944-7558-115-5-433-DHulst1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2008.11.075","article-title":"Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor\/ataxia syndrome (FXTAS).","volume":"1253","author":"D'Hulst","year":"2009","journal-title":"Brain Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-DHulst2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.tins.2007.06.003","article-title":"The GABAA receptor: A novel target for treatment of fragile X?","volume":"30","author":"D'Hulst","year":"2007","journal-title":"Trends in Neurosciences"},{"key":"2020060218481045700_i1944-7558-115-5-433-Danbolt1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake.","volume":"65","author":"Danbolt","year":"2001","journal-title":"Progress in Neurobiology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Dansie1","article-title":"[MMP-9 expression is regulated by mGluR5 activity in hippocampal neurons.].","author":"Dansie","year":"2009"},{"key":"2020060218481045700_i1944-7558-115-5-433-deDiegoOtero1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/npp.2008.152","article-title":"\u03b1-tocopherol protects against oxidative stress in the fragile X knockout mouse: An experimental therapeutic approach for the Fmr1 deficiency.","volume":"34","author":"de Diego-Otero","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"2020060218481045700_i1944-7558-115-5-433-deVrij1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.nbd.2008.04.002","article-title":"Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 knock-out mice.","volume":"31","author":"de Vrij","year":"2008","journal-title":"Neurobiology of Disease"},{"key":"2020060218481045700_i1944-7558-115-5-433-Eisen1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2165\/00002018-199818060-00004","article-title":"Minocycline-induced pigmentation. Incidence, prevention and management.","volume":"18","author":"Eisen","year":"1998","journal-title":"Drug Safety"},{"key":"2020060218481045700_i1944-7558-115-5-433-ElHallak1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jpeds.2008.03.013","article-title":"Chronic minocycline-induced autoimmunity in children.","volume":"153","author":"El-Hallak","year":"2008","journal-title":"Journal of Pediatrics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Elewa1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1592\/phco.26.4.515","article-title":"Minocycline for short-term neuroprotection.","volume":"24","author":"Elewa","year":"2006","journal-title":"Pharmacotherapy"},{"key":"2020060218481045700_i1944-7558-115-5-433-Elkayam1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0002-9343(98)00325-8","article-title":"Clinical and immunological study of 7 patients with minocycline-induced autoimmune phenomena.","volume":"105","author":"Elkayam","year":"1998","journal-title":"American Journal of Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Ethell1","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/jnr.21273","article-title":"Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets.","volume":"85","author":"Ethell","year":"2007","journal-title":"Journal of Neuroscience Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-Farzin1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s10803-009-0744-1","article-title":"Brief report: Visual processing of faces in individuals with fragile X syndrome: An eye tracking study.","volume":"39","author":"Farzin","year":"2009","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"2020060218481045700_i1944-7558-115-5-433-Farzin2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.visres.2008.03.019","article-title":"Contrast detection in infants with fragile X syndrome.","volume":"48","author":"Farzin","year":"2008","journal-title":"Vision Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-FernandezCarvajal1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2353\/jmoldx.2009.080173","article-title":"Screening for expanded alleles of the FMR1 gene in blood spots from newborn males in a Spanish population.","volume":"11","author":"Fernandez-Carvajal","year":"2009","journal-title":"Journal of Molecular Diagnostics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Good1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2133.2003.05497.x","article-title":"Minocycline: Stain devil?","volume":"149","author":"Good","year":"2003","journal-title":"British Journal of Dermatology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Gordon1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/17482960802195632","article-title":"A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS.","volume":"9","author":"Gordon","year":"2008","journal-title":"Amyotrophic Lateral Sclerosis"},{"key":"2020060218481045700_i1944-7558-115-5-433-Hagerman1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/jmg.2008.059055","article-title":"The fragile X prevalence paradox.","volume":"45","author":"Hagerman","year":"2008","journal-title":"Journal of Medical Genetics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Hagerman2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00004703-200602000-00012","article-title":"Lessons from fragile X regarding neurobiology, autism, and neurodegeneration.","volume":"27","author":"Hagerman","year":"2006","journal-title":"Journal of Developmental & Behavioral Pediatrics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Hagerman3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/157339608783565770","article-title":"The fragile X family of disorders: A model for autism and targeted treatments.","volume":"4","author":"Hagerman","year":"2008","journal-title":"Current Pediatric Reviews"},{"key":"2020060218481045700_i1944-7558-115-5-433-Hessl1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ajmg.b.30858","article-title":"Prepulse inhibition in fragile X syndrome: Feasibility, reliability, and implications for treatment.","volume":"150B","author":"Hessl","year":"2009","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"issue":"2\u20133","key":"2020060218481045700_i1944-7558-115-5-433-Imbesi1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neulet.2008.10.006","article-title":"Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors.","volume":"447","author":"Imbesi","year":"2008","journal-title":"Neuroscience Letters"},{"key":"2020060218481045700_i1944-7558-115-5-433-Jonas1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00007691-198206000-00002","article-title":"Minocycline.","volume":"4","author":"Jonas","year":"1982","journal-title":"Therapeutic Drug Monitoring"},{"key":"2020060218481045700_i1944-7558-115-5-433-Kim1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","article-title":"Minocycline and neurodegenerative diseases.","volume":"196","author":"Kim","year":"2009","journal-title":"Behavioral Brain Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-Kooy1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0168-9525(03)00017-9","article-title":"Of mice and the fragile X syndrome.","volume":"19","author":"Kooy","year":"2003","journal-title":"Trends in Genetics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Kriz1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/nbdi.2002.0487","article-title":"Minocycline slows disease progression in a mouse model of amyotropic lateral sclerosis.","volume":"10","author":"Kriz","year":"2002","journal-title":"Neurobiology of Disease"},{"key":"2020060218481045700_i1944-7558-115-5-433-LaPorta1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-051X.2005.00646.x","article-title":"Minocycline-associated intra-oral soft tissue pigmentation: Clinicopathologic correlation and review.","volume":"32","author":"LaPorta","year":"2005","journal-title":"Journal of Clinical Periodotology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Lawson1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/rheumatology\/40.3.329","article-title":"Minocycline-induced lupus: Clinical features and response to rechallenge.","volume":"40","author":"Lawson","year":"2001","journal-title":"Rheumatology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Lee1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1089\/089771503770195867","article-title":"Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat.","volume":"20","author":"Lee","year":"2003","journal-title":"Journal of Neurotrauma"},{"issue":"146","key":"2020060218481045700_i1944-7558-115-5-433-Liu1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.STR.0000251791.64910.cd","article-title":"Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia.","volume":"38","author":"Liu","year":"2007","journal-title":"Stroke"},{"key":"2020060218481045700_i1944-7558-115-5-433-Lord1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1005592401947","article-title":"The Autism Diagnostic Observation Schedule-Generic: A standard measure of social and communication deficits associated with the spectrum of autism.","volume":"30","author":"Lord","year":"2000","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"2020060218481045700_i1944-7558-115-5-433-Lord2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","article-title":"Autism Diagnostic Interview-Revised: A revised version of a Diagnostic Interview for Caregivers of Individuals With Possible Pervasive Developmental Disorders.","volume":"24","author":"Lord","year":"1994","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"2020060218481045700_i1944-7558-115-5-433-Margolis1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2133.2007.08056.x","article-title":"Association or lack of association between tetracycline class antibiotics used for acne vulgaris and lupus erythematosus.","volume":"157","author":"Margolis","year":"2007","journal-title":"British Journal of Dermatology"},{"key":"2020060218481045700_i1944-7558-115-5-433-McBride1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neuron.2005.01.038","article-title":"Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.","volume":"45","author":"McBride","year":"2005","journal-title":"Neuron"},{"issue":"1","key":"2020060218481045700_i1944-7558-115-5-433-Nagarajan1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1440-1754.2000.00430.x","article-title":"Tetracycline-induced benign intracranial hypertension.","volume":"36","author":"Nagarajan","year":"2000","journal-title":"Journal of Paediatrics Child Health"},{"key":"2020060218481045700_i1944-7558-115-5-433-Noble1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1096\/fj.08-113795","article-title":"Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.","volume":"23","author":"Noble","year":"2009","journal-title":"Journal of the Federation of American Societies For Experimental Biology (FASEB)"},{"issue":"Spec No.\u00a02","key":"2020060218481045700_i1944-7558-115-5-433-Oostra1","doi-asserted-by":"crossref","first-page":"R249","DOI":"10.1093\/hmg\/ddg298","article-title":"A fragile balance: FMR1 expression levels.","volume":"12","author":"Oostra","year":"2003","journal-title":"Human Molecular Genetics"},{"issue":"1171","key":"2020060218481045700_i1944-7558-115-5-433-Porter1","article-title":"Minocycline-induced lupus: A case series.","volume":"116","author":"Porter","year":"2003","journal-title":"New Zealand Journal of Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Qin1","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1523\/JNEUROSCI.0093-05.2005","article-title":"Postadolescent changes in regional cerebral protein synthesis: An in vivo study in the FMR1 null mouse.","volume":"25","author":"Qin","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"2020060218481045700_i1944-7558-115-5-433-Sanchez1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-4632.2004.02108.x","article-title":"Tetracycline and other tetracycline-derivate staining of the teeth and oral cavity.","volume":"43","author":"Sanchez","year":"2004","journal-title":"International Journal of Dermatology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Schlienger1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000018387","article-title":"Minocycline-induced lupus.","volume":"200","author":"Schlienger","year":"2000","journal-title":"Dermatology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Shepherd1","first-page":"239","article-title":"Severe complication of a commonly prescribed drug: Minocycline-induced lupus.","volume":"15","author":"Shepherd","year":"2002","journal-title":"Journal of the American Board of Family Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Shetty1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/000992280204100402","article-title":"Tetracyclines in pediatrics revisited.","volume":"41","author":"Shetty","year":"2002","journal-title":"Clinical Pediatrics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Shiri1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.7326\/0003-4819-127-2-199707150-00030","article-title":"Intracranial hypertension and minocycline.","volume":"127","author":"Shiri","year":"1997","journal-title":"Annals of Internal Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Smith1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.clinthera.2005.09.005","article-title":"Safety of doxycycline and minocycline: A systematic review.","volume":"27","author":"Smith","year":"2005","journal-title":"Clinical Therapeutics"},{"key":"2020060218481045700_i1944-7558-115-5-433-Sternlicht1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior.","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annual Review of Cell Developmental Biology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Stirling1","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1523\/JNEUROSCI.5275-03.2004","article-title":"Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.","volume":"24","author":"Stirling","year":"2004","journal-title":"Journal of Neuroscience"},{"issue":"Pt 1","key":"2020060218481045700_i1944-7558-115-5-433-Sullivan1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2788.2006.00899.x","article-title":"Behavioural equivalents of anxiety in children with fragile X syndrome: Parent and teacher report.","volume":"51","author":"Sullivan","year":"2007","journal-title":"Journal of Intellectual Disability Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-Teitelbaum1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archpedi.152.11.1132","article-title":"Minocycline-related autoimmune hepatitis.","volume":"152","author":"Teitelbaum","year":"1998","journal-title":"Archives of Pediatrics & Adolescent Medicine"},{"key":"2020060218481045700_i1944-7558-115-5-433-Tournigand1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1191\/096120399678841025","article-title":"Minocycline-induced clinical and biological lupus-like disease.","volume":"8","author":"Tournigand","year":"1999","journal-title":"Lupus"},{"key":"2020060218481045700_i1944-7558-115-5-433-Tredwin1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/154405910508400703","article-title":"Drug-induced disorders of teeth.","volume":"84","author":"Tredwin","year":"2005","journal-title":"Journal of Dental Research"},{"key":"2020060218481045700_i1944-7558-115-5-433-vanSteensel1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mehy.2003.12.040","article-title":"Why minocycline can cause systemic lupus\u2014A hypothesis and suggestions for therapeutic interventions based on it.","volume":"63","author":"van Steensel","year":"2004","journal-title":"Medical Hypotheses"},{"key":"2020060218481045700_i1944-7558-115-5-433-Verkerk1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR\u20131) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"2020060218481045700_i1944-7558-115-5-433-Wang1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1385\/MN:32:3:237","article-title":"Phosphorylation of AMPA receptors: Mechanisms and synaptic plasticity.","volume":"32","author":"Wang","year":"2005","journal-title":"Molecular Neurobiology"},{"key":"2020060218481045700_i1944-7558-115-5-433-Well1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/brain\/awg178","article-title":"Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice.","volume":"126","author":"Well","year":"2003","journal-title":"Brain"}],"container-title":["American Journal on Intellectual and Developmental Disabilities"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/ajidd\/article-pdf\/115\/5\/433\/2024209\/1944-7558-115_5_433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/ajidd\/article-pdf\/115\/5\/433\/2024209\/1944-7558-115_5_433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:35:45Z","timestamp":1768322145000},"score":1,"resource":{"primary":{"URL":"https:\/\/meridian.allenpress.com\/ajidd\/article\/115\/5\/433\/1110\/Side-Effects-of-Minocycline-Treatment-in-Patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,1]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9,1]]}},"URL":"https:\/\/doi.org\/10.1352\/1944-7558-115.5.433","relation":{},"ISSN":["1944-7558","1944-7515"],"issn-type":[{"value":"1944-7558","type":"electronic"},{"value":"1944-7515","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9,1]]}}}