{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:09:17Z","timestamp":1771880957383,"version":"3.50.1"},"reference-count":38,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Few studies exist of developmental trajectories in children with intellectual disability, and none for those with subtelomeric deletions. We compared developmental trajectories of children with Wolf-Hirschhorn syndrome to other genetic disorders. We recruited 106 children diagnosed with fragile X, Williams-Beuren syndrome, or Wolf-Hirschhorn syndrome, assessing their intellectual and adaptive behavior abilities. We retested 61 children 2\u00a0years later. We compared Time 1 and Time 2 difference scores related to genetic disorder, age, initial IQ, or adaptive behavior composite. Results show genetic disorder and initial IQ score were significant factors for IQ differences, but only genetic disorder affected adaptive behavior differences. Results suggest different gene-brain-behavior pathways likely exist for these genetic disorders. Different developmental trajectories will influence the type and intensity of intervention implemented by caregivers.<\/jats:p>","DOI":"10.1352\/1944-7558-117.2.167","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T14:34:33Z","timestamp":1334846073000},"page":"167-179","source":"Crossref","is-referenced-by-count":24,"title":["Developmental Trajectories in Syndromes With Intellectual Disability, With a Focus on Wolf-Hirschhorn and Its Cognitive\u2013Behavioral Profile"],"prefix":"10.1080","volume":"117","author":[{"given":"Gene S.","family":"Fisch","sequence":"first","affiliation":[{"name":"New York University Colleges of Dentistry and Nursing and Yeshiva University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Center for Genetic Testing, Tulsa, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia N.","family":"Howard-Peebles","sequence":"additional","affiliation":[{"name":"Genetics & IVF Institute, Fairfax, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette J. A.","family":"Holden","sequence":"additional","affiliation":[{"name":"Ongwanada Resource Centre, Queens University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Tarleton","sequence":"additional","affiliation":[{"name":"Fullerton Genetics Center, Asheville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Simensen","sequence":"additional","affiliation":[{"name":"Greenwood Genetics Center, Greenwood, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatino","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Stella Maris Clinical Research Institute for Child and Adolescent Neurology and Psychiatry, Calambrone (Pisa), 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