{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:04:39Z","timestamp":1792706679308,"version":"4.5.0"},"reference-count":70,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n \u200a=\u200a 130, M age \u200a=\u200a 17.19), Fragile X syndrome (n \u200a=\u200a 182, M age \u200a=\u200a 16.94), and autism spectrum disorder (n \u200a=\u200a 142, M age \u200a=\u200a 15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population.<\/jats:p>","DOI":"10.1352\/1944-7558-118.1.55","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T19:43:28Z","timestamp":1357760608000},"page":"55-73","source":"Crossref","is-referenced-by-count":51,"title":["Delineating the Profile of Autism Spectrum Disorder Characteristics in Cornelia de Lange and Fragile X Syndromes"],"prefix":"10.1080","volume":"118","author":[{"given":"Joanna","family":"Moss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Oliver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Richards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","reference":[{"key":"2020060217503698000_i1944-7558-118-1-55-Arron1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2788.2010.01337.x","article-title":"Delineation of behavioural phenotypes in genetic syndromes. 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