{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:04:07Z","timestamp":1790424247549,"version":"4.1.0"},"reference-count":52,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rett syndrome (RTT) is a severe neurodevelopmental disorder resulting from mutations of the MECP2 gene. Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and abnormal stress responses have been observed in animal models of RTT, but little is known about HPA axis function among individuals with RTT. Diurnal salivary cortisol patterns from 30 females with RTT were examined in relation to mutation type, medication use, and features of the RTT behavioral phenotype. Cortisol patterns were significantly related to mutation severity, anticonvulsant medication status, and bruxism (tooth grinding). This study provides preliminary support for the hypothesis that RTT may be at risk for outcomes associated with aberrant HPA axis function, and that this risk may be mediated by mutation type.<\/jats:p>","DOI":"10.1352\/1944-7558-125.5.353","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T14:14:32Z","timestamp":1600265672000},"page":"353-368","source":"Crossref","is-referenced-by-count":8,"title":["Associations Among Diurnal Salivary Cortisol Patterns, Medication Use, and Behavioral Phenotype Features in a Community Sample of Rett Syndrome"],"prefix":"10.1080","volume":"125","author":[{"given":"Breanne J.","family":"Byiers","sequence":"first","affiliation":[{"name":"Breanne J. Byiers and Ameante Payen, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameante","family":"Payen","sequence":"additional","affiliation":[{"name":"Breanne J. Byiers and Ameante Payen, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Feyma","sequence":"additional","affiliation":[{"name":"Timothy Feyma, Gillette Children's Specialty Healthcare, St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Panoskaltsis-Mortari","sequence":"additional","affiliation":[{"name":"Angela Panoskaltsis-Mortari, Michael J. Ehrhardt, and Frank J. Symons, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Angela Panoskaltsis-Mortari, Michael J. Ehrhardt, and Frank J. Symons, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Symons","sequence":"additional","affiliation":[{"name":"Angela Panoskaltsis-Mortari, Michael J. Ehrhardt, and Frank J. Symons, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"2020091613410743100_i1944-7515-125-5-353-Amir1","doi-asserted-by":"crossref","unstructured":"Amir,\n              R. E.,\n            \n            \n              Van den Veyver,\n              I. B.,\n            \n            \n              Wan,\n              M.,\n            \n            \n              Tran,\n              C. Q.,\n            \n            \n              Francke,\n              U.,\n             &\n\t\t\t\t\t\tZoghbi,H. 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K.,\n            \n            \n              Annese,\n              F.,\n            \n            \n              McNair,\n              L.,\n            \n            \n              Skinner,\n              S. A.,\n            \n            \n              Lee,\n              H-S.,\n            \n            \n              Neul,\n              J. L.,\n             &\n\t\t\t\t\t\tGlaze,D. G.\n          (2012).\n\t\t\t\t\tGastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome.\n\t\t\t\t\tJournal of Pediatric Gastroenterology and Nutrition,\n\t\t\t\t\t55(3),\n\t\t\t\t\t292\u2013\n\t\t\t\t\t298.\n\t\t\t\t\thttps:\/\/doi.org\/10.1097\/MPG.0b013e31824b6159","DOI":"10.1097\/MPG.0b013e31824b6159"},{"key":"2020091613410743100_i1944-7515-125-5-353-Motil2","doi-asserted-by":"crossref","unstructured":"Motil,\n              K. J.,\n            \n            \n              Schultz,\n              R. J.,\n            \n            \n              Abrams,\n              S.,\n            \n            \n              Ellis,\n              K. J.,\n             &\n\t\t\t\t\t\tGlaze,D. G.\n          (2006).\n\t\t\t\t\tFractional calcium absorption is increased in girls with Rett syndrome.\n\t\t\t\t\tJournal of Pediatric Gastroenterology and Nutrition,\n\t\t\t\t\t42(4),\n\t\t\t\t\t419\u2013\n\t\t\t\t\t426.\n\t\t\t\t\thttps:\/\/doi.org\/10.1097\/01.mpg.0000189370.22288.0c","DOI":"10.1097\/01.mpg.0000189370.22288.0c"},{"key":"2020091613410743100_i1944-7515-125-5-353-Mount1","doi-asserted-by":"crossref","unstructured":"Mount,\n              R. H.,\n            \n            \n              Charman,\n              T.,\n            \n            \n              Hastings,\n              R. 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K.,\n            \n            \n              Feyma,\n              T.,\n            \n            \n              Beisang,\n              A.,\n            \n            \n              Dinh,\n              T.,\n            \n            \n              Suter,\n              B.,\n            \n            \n              Anagnostou,\n              E.,\n            \n            \n              Snape,\n              M.,\n            \n            \n              Horrigan,\n              J.,\n             &\n\t\t\t\t\t\tJones,N. E.\n          (2015).\n\t\t\t\t\tImproving treatment trial outcomes for Rett syndrome: The development of Rett-specific anchors for the clinical global impression scale.\n\t\t\t\t\tJournal of Child Neurology,\n\t\t\t\t\t30(13),\n\t\t\t\t\t1743\u2013\n\t\t\t\t\t1748.","DOI":"10.1177\/0883073815579707"},{"key":"2020091613410743100_i1944-7515-125-5-353-Nuber1","doi-asserted-by":"crossref","unstructured":"Nuber,\n              U. 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C.,\n            \n            \n              W\u00fcst,\n              S.,\n            \n            \n              Dockray,\n              S.,\n            \n            \n              Smyth,\n              N.,\n            \n            \n              Evans,\n              P.,\n            \n            \n              Hellhammer,\n              D. H.,\n            \n            \n              Miller,\n              R.,\n            \n            \n              Wetherell,\n              M. A.,\n            \n            \n              Lupien,\n              S. 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H.,\n            \n            \n              Van Calster,\n              B.,\n            \n            \n              Pinna Puissant,\n              S.,\n             &\n\t\t\t\t\t\tVan Huffel,S.\n          (2008).\n\t\t\t\t\tSelf-reported symptoms of depressed mood, trait anxiety and aggressive behavior in post-pubertal adolescents: Associations with diurnal cortisol profiles.\n\t\t\t\t\tHormones and Behavior,\n\t\t\t\t\t54(2),\n\t\t\t\t\t253\u2013\n\t\t\t\t\t257.\n\t\t\t\t\thttps:\/\/doi.org\/10.1016\/j.yhbeh.2008.03.015","DOI":"10.1016\/j.yhbeh.2008.03.015"},{"key":"2020091613410743100_i1944-7515-125-5-353-WeeseMayer1","doi-asserted-by":"crossref","unstructured":"Weese-Mayer,\n              D. E.,\n            \n            \n              Lieske,\n              S. P.,\n            \n            \n              Boothby,\n              C. M.,\n            \n            \n              Kenny,\n              A. S.,\n            \n            \n              Bennett,\n              H. L.,\n            \n            \n              Silvestri,\n              J. M.,\n             &\n\t\t\t\t\t\tRamirez,J.-M.\n\t\t\t\t\t\n          (2006).\n\t\t\t\t\tAutonomic nervous system dysregulation: Breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome.\n\t\t\t\t\tPediatric Research,\n\t\t\t\t\t60(4),\n\t\t\t\t\t443.","DOI":"10.1203\/01.pdr.0000238302.84552.d0"},{"key":"2020091613410743100_i1944-7515-125-5-353-West1","doi-asserted-by":"crossref","unstructured":"West,\n              B. T.,\n            \n            \n              Welch,\n              K. B.,\n             &\n\t\t\t\t\t\tGalecki,A. T.\n          (2014).\n\t\t\t\t\tLinear mixed models: A practical guide using statistical software, second edition.\n\t\t\t\t\tChapman and Hall\/CRC.\n\t\t\t\t\thttps:\/\/doi.org\/10.1201\/b17198","DOI":"10.1201\/b17198"}],"container-title":["American Journal on Intellectual and Developmental Disabilities"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/ajidd\/article-pdf\/125\/5\/353\/2590548\/i1944-7515-125-5-353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/ajidd\/article-pdf\/125\/5\/353\/2590548\/i1944-7515-125-5-353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:34:44Z","timestamp":1768322084000},"score":1,"resource":{"primary":{"URL":"https:\/\/meridian.allenpress.com\/ajidd\/article\/125\/5\/353\/444061\/Associations-Among-Diurnal-Salivary-Cortisol"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,16]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1352\/1944-7558-125.5.353","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738756496.793586480","asserted-by":"object"}]},"ISSN":["1944-7558","1944-7515"],"issn-type":[{"value":"1944-7558","type":"electronic"},{"value":"1944-7515","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}