{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:24:11Z","timestamp":1777533851868,"version":"3.51.4"},"reference-count":0,"publisher":"Project MUSE","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["pbm"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p xml:lang=\"en\">\n\nCeliac disease (gluten sensitive enteropathy) is\na condition affecting the small bowel, characterized by permanent\nintolerance to dietary gluten, and giving rise to varying degrees of\nmalabsorption and diarrhea. With the advent of sensitive screening tests,\nthe condition is being increasingly diagnosed. Celiac disease is more\ncommon in the Irish and in those of Irish descent. Simoons (1978, 1981)\nhypothesized that the present-day prevalence of celiac disease across\nEurope is related to the interaction between genetic gradients, largely\ndetermined by the advance of agriculture, and historical patterns of\ncereal ingestion. This essay examines Simoons' hypothesis as it relates to\nIreland, reviews the ethnic and genetic mix of those living on the island\nof Ireland and aspects of Irish dietary history, and considers how these\nfactors may have combined to result in a high frequency of celiac disease.\n\n<\/jats:p>","DOI":"10.1353\/pbm.2001.0045","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T02:46:45Z","timestamp":1170816405000},"page":"342-352","source":"Crossref","is-referenced-by-count":20,"title":["Why is Celiac Disease So Common in Ireland?"],"prefix":"10.1353","volume":"44","author":[{"given":"Cornelius C","family":"Cronin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus","family":"Shanahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"147","container-title":["Perspectives in Biology and Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T17:44:56Z","timestamp":1705686296000},"score":1,"resource":{"primary":{"URL":"https:\/\/muse.jhu.edu\/article\/26061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,6]]}},"URL":"https:\/\/doi.org\/10.1353\/pbm.2001.0045","relation":{},"ISSN":["1529-8795"],"issn-type":[{"value":"1529-8795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}