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At necropsy, there was multifocal mural gastric, intestinal, and urinary bladder thickening, concurrent bilateral hydroureter and hydronephrosis, and extensive fibrous abdominal adhesions. Histologic evaluation revealed intestinal adenocarcinoma with coelomic metastasis to the stomach and urinary bladder. The adenocarcinoma was evaluated using histo-chemistry and electron microscopy. Paneth, enteroendocrine, and goblet cell differentiation was documented in primary and metastatic sites. This unique presentation of intestinal adenocarcinoma has not previously been reported in the opossum or any other animals. Intestinal neoplasia with Paneth cell differentiation is extremely rare and has been reported in humans with familial adenomatous polyposis. <\/jats:p>","DOI":"10.1354\/vp.36-5-463","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:14:16Z","timestamp":1051215256000},"page":"463-468","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Metastatic Intestinal Adenocarcinoma with Differentiation into Multiple Morphologic Cell Types in a Virginia Opossum"],"prefix":"10.1177","volume":"36","author":[{"given":"M. R.","family":"Prater","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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