{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:14:56Z","timestamp":1784830496693,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p> Two weeks before dying of congestive heart failure, a juvenile black rhinoceros ( Diceros bicornis minor) received a single low dose of doxorubicin as part of combination chemotherapy for acute lymphoblastic leukemia. Diffuse hemosiderosis was present at necropsy in a pattern indicative of dietary iron overload, but unique iron-positive degenerative lesions were found in isolated myocardiocytes. Serum analyses revealed hyperferremia, 87% transferrin saturation, and 5- to 10-fold elevations in ferritin concentration, reflecting markedly increased tissue iron stores. Since both toxic and therapeutic effects of anthracyclines are mediated by formation of reactive free radicals via iron-catalyzed reactions, these observations suggest that iron overload may have enhanced myocardial susceptibility to cardiotoxic effects of doxorubicin. Impairments in other myocardial antioxidant defenses, such as deficiencies in catalase and glutathione S-transferase that are known to exist in rhinoceros erythrocytes, may have been underlying factors contributing to an inherent sensitivity of rhinoceros tissues to oxidant-induced injury. <\/jats:p>","DOI":"10.1354\/vp.37-1-86","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:15:20Z","timestamp":1051215320000},"page":"86-88","source":"Crossref","is-referenced-by-count":17,"title":["Anthracycline Cardiotoxicity in a Black Rhinoceros (<i>Diceros bicornis<\/i>)"],"prefix":"10.1177","volume":"37","author":[{"given":"D. E.","family":"Paglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Radcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"bibr1-vp.37-1-86","first-page":"47","volume-title":"Cancer Treatment and the Heart","author":"Doroshow JH","year":"1992"},{"key":"bibr2-vp.37-1-86","first-page":"9","volume-title":"Cancer Treatment and the Heart","author":"Gianni L","year":"1992"},{"key":"bibr3-vp.37-1-86","first-page":"230","volume":"23","author":"Kock N","year":"1992","journal-title":"J Zoo Wildl Med"},{"key":"bibr4-vp.37-1-86","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90001-1"},{"key":"bibr5-vp.37-1-86","unstructured":"5 Paglia DE, Dennis P: Role of chronic iron overload in multiple disorders of captive black rhinoceroses (Diceros bicornis). Proc Am Assoc Zoo Vets 1999 (in press)"},{"key":"bibr6-vp.37-1-86","first-page":"217","volume":"1992","author":"Paglia DE","journal-title":"Proc Am Assoc Zoo Vets"},{"key":"bibr7-vp.37-1-86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1090.1993.tb03510.x"},{"key":"bibr8-vp.37-1-86","first-page":"37","volume":"1996","author":"Paglia DE","journal-title":"Proc Am Assoc Zoo Vets"},{"key":"bibr9-vp.37-1-86","unstructured":"9 Radcliffe RW, Paglia DE, Couto CG: Acute lymphoblastic leukemia in a juvenile southern black rhinoceros (Diceros bicornis minor). J Zoo Wildl Med 1999 (in press)"},{"key":"bibr10-vp.37-1-86","first-page":"525","volume":"26","author":"Smith JE","year":"1995","journal-title":"J Zoo Wildl Med"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.37-1-86","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.37-1-86","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.37-1-86","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T06:06:59Z","timestamp":1740982019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.37-1-86"}},"subtitle":["Evidence for Impaired Antioxidant Capacity Compounded by Iron Overload"],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1354\/vp.37-1-86"],"URL":"https:\/\/doi.org\/10.1354\/vp.37-1-86","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}