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Postmortem examination confirmed the presence of a pulmonic valve mass that extended along the pulmonary trunk and into the left pulmonary artery. Multiple pale nodules were observed in the right lung. Microscopic examinations of the pulmonary artery mass and the lung nodules revealed a pleomorphic population of spindle cells often arranged in broad bands containing strap-like nuclei and eosinophilic cytoplasm devoid of cross striations. The neoplastic cells expressed vimentin and alpha-smooth muscle actin but did not express desmin, CD31, factor VIII, or S100. The presentation, histological features, immunocytochemical profiles, and behavior of this tumor were indicative of a primary pulmonary artery leiomyosarcoma with lung metastasis. <\/jats:p>","DOI":"10.1354\/vp.37-6-663","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:16:52Z","timestamp":1051215412000},"page":"663-666","source":"Crossref","is-referenced-by-count":22,"title":["Primary Pulmonary Artery Leiomyosarcoma in an Adult Dog"],"prefix":"10.1177","volume":"37","author":[{"given":"J. J.","family":"Callanan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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