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The neoplasm penetrated through the wall of the caudal vena cava. A diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. Immunohistochemically, the neoplastic cells expressed chromogranin A, substance P, synaptophysin, Leu-7, protein gene product 9.5, methionine- enkephalin, S100 protein, and galanin. Multiple metastatic tumors were found in the kidneys, spleen, lungs, heart, and liver. <\/jats:p>","DOI":"10.1354\/vp.38-4-447","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:18:19Z","timestamp":1051215499000},"page":"447-450","source":"Crossref","is-referenced-by-count":18,"title":["Immunohistochemical Evaluation of a Malignant Pheochromocytoma in a Wolfdog"],"prefix":"10.1177","volume":"38","author":[{"given":"T.","family":"Sako","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Taniyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"bibr1-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350121"},{"key":"bibr2-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00464.x"},{"key":"bibr3-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-6-1372"},{"key":"bibr4-vp.38-4-447","first-page":"1610","volume":"191","author":"Bouayad H","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"bibr5-vp.38-4-447","first-page":"576","volume-title":"Tumors in Domestic Animals","author":"Capen CC","year":"1990","edition":"3"},{"key":"bibr6-vp.38-4-447","first-page":"1113","volume-title":"Pathologic Basis of Disease","author":"Crum CP","year":"1994","edition":"5"},{"key":"bibr7-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80012-X"},{"key":"bibr8-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1177\/030098589803500413"},{"key":"bibr9-vp.38-4-447","first-page":"429","volume":"8","author":"Fraga M","year":"1993","journal-title":"Histol Histopathol"},{"key":"bibr10-vp.38-4-447","first-page":"509","volume-title":"Pathology","author":"Gotlieb AI","year":"1999","edition":"3"},{"key":"bibr11-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1007\/BF00750574"},{"key":"bibr12-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420010123020"},{"key":"bibr13-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(89)90097-1"},{"key":"bibr14-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb19603.x"},{"key":"bibr15-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00224-6"},{"key":"bibr16-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.17.15"},{"key":"bibr17-vp.38-4-447","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(84)50080-1"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.38-4-447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.38-4-447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.38-4-447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T03:58:14Z","timestamp":1738036694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.38-4-447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1354\/vp.38-4-447"],"URL":"https:\/\/doi.org\/10.1354\/vp.38-4-447","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}