{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:21:35Z","timestamp":1760887295528,"version":"3.38.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p> Avian leukosis virus subgroup J has a high tropism for myeloid lineage cells and frequently induces neoplastic transformation of myelocytes. The impact of congenital avian leukosis virus subgroup J infection on the function of circulating heterophils and susceptibility to staphylococcal infection was investigated. Six-week-old broiler chickens negative for exogenous avian leukosis viruses or congenitally infected with avian leukosis virus subgroup J were inoculated intravenously with 106 colony-forming units of Staphylococcus aureus, and pre- and postinoculation heterophil function was assessed. All chickens developed a leukocytosis with heterophilia after inoculation, but total leukocyte and heterophil counts were significantly higher in leukosis-negative chickens than in virus-infected chickens. Tenosynovitis was more severe in leukosisnegative chickens, and 2\/10 (20%) of the virus-infected chickens had no histologic evidence of tenosynovitis. Osteomyelitis in the tibiotarsus or tarsometatarsus developed in 5\/10 (50%) of the chickens in each group. S. aureus was recovered from the hock joint of 6\/10 (60%) of the chickens in each group. Heterophils from all chickens exhibited similar phagocytic ability pre- and postinoculation. Heterophils from virus-infected chickens exhibited less bactericidal ability preinoculation than did heterophils from leukosis-negative chickens. However, postinoculation bactericidal ability was similar in both groups. Avian leukosis virus subgroup J provirus was present in heterophils isolated from congenitally infected chickens. Heterophils isolated from broiler chickens congenitally infected with avian leukosis virus subgroup J exhibit no significant functional deficits, and infected and uninfected chickens exhibit similar susceptibility to staphylococcal infection. <\/jats:p>","DOI":"10.1354\/vp.38-5-519","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:18:57Z","timestamp":1051215537000},"page":"519-527","source":"Crossref","is-referenced-by-count":14,"title":["Heterophil Function and Resistance to Staphylococcal Challenge in Broiler Chickens Naturally Infected with Avian Leukosis Virus Subgroup J"],"prefix":"10.1177","volume":"38","author":[{"given":"N. L.","family":"Stedman","sequence":"first","affiliation":[{"name":"Departments of Veterinary Pathology and Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P.","family":"Brown","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathology and Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"R. L.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathology and Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. I.","family":"Bounous","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathology and Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"bibr1-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1592297"},{"key":"bibr2-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800510"},{"key":"bibr3-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1591650"},{"key":"bibr4-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400205"},{"key":"bibr5-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/76.2.280"},{"key":"bibr6-vp.38-5-519","first-page":"1147","volume-title":"Schalm's Veterinary Hematology","author":"Bounous DI","year":"2000","edition":"5"},{"key":"bibr7-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1007\/BF00368459"},{"key":"bibr8-vp.38-5-519","first-page":"6033","volume":"47","author":"Cummins TJ","year":"1987","journal-title":"Cancer Res"},{"key":"bibr9-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080605"},{"key":"bibr10-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1592112"},{"key":"bibr11-vp.38-5-519","first-page":"333","volume":"110","author":"Emslie KR","year":"1983","journal-title":"Am J Pathol"},{"key":"bibr12-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711410206"},{"key":"bibr13-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1128\/iai.45.1.87-93.1984"},{"key":"bibr14-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199410000-00005"},{"key":"bibr15-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.7.972"},{"key":"bibr16-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1591559"},{"key":"bibr17-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1591096"},{"key":"bibr18-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10615"},{"key":"bibr19-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1994.tb03424.x"},{"key":"bibr20-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(90)84244-O"},{"key":"bibr21-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-4-801"},{"key":"bibr22-vp.38-5-519","first-page":"1167","volume":"6","author":"Payne LN","year":"1992","journal-title":"Leukemia"},{"key":"bibr23-vp.38-5-519","first-page":"3617","volume":"42","author":"Price JA","year":"1982","journal-title":"Cancer Res"},{"key":"bibr24-vp.38-5-519","first-page":"4764","volume":"50","author":"Rao A","year":"1990","journal-title":"Cancer Res"},{"key":"bibr25-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(82)90403-2"},{"key":"bibr26-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.3.333"},{"key":"bibr27-vp.38-5-519","first-page":"546","volume":"3","author":"Schaumann R","year":"1998","journal-title":"Eur J Med Res"},{"key":"bibr28-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(98)00022-7"},{"key":"bibr29-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.2307\/1592664"},{"key":"bibr30-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(91)90042-B"},{"key":"bibr31-vp.38-5-519","doi-asserted-by":"publisher","DOI":"10.1080\/03079450050118458"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.38-5-519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.38-5-519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.38-5-519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T14:50:23Z","timestamp":1740927023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.38-5-519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1354\/vp.38-5-519"],"URL":"https:\/\/doi.org\/10.1354\/vp.38-5-519","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"type":"print","value":"0300-9858"},{"type":"electronic","value":"1544-2217"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}