{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:27:35Z","timestamp":1784831255306,"version":"3.55.0"},"reference-count":69,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p> A retrospective study was performed to characterize malignant lymphomas of 16 Simian immunodeficiency virus (SIV)-infected rhesus monkeys ( Macaca mulatta), 2\u20139 years of age, on the basis of clinical data, histologic and immunophenotypic results, and cell death indices compiled with the TdT-mediated X-duTP nick end labeling method. We particularly focused on providing immunohistochemical evidence of expression products of EBNA2, Bcl2, c-Myc, P21, P53, and Bc16. Results were compared with data from the literature on human HIV-associated lymphomas. According to the updated Kiel classification, the lymphomas were classified as 11 centroblastic lymphomas, three immunoblastic lymphomas, one Burkitt-like lymphoma, and one immunocytoma. Using antibodies to CD20, the B-cell origin of tumor cells was demonstrated. SIV antigen was not demonstrated in the tumor cells. Infection with rhesus lymphocryptovirus was present in 94% of the monkeys. Lymphomas revealed expression of Bc12 in 15\/16 (94%), c-Myc in 14\/16 (88%), P21 in 10\/16 (63%), P53 in 12\/16 (75%), and Bc16 in 1\/16 (6%) monkeys. This study provided evidence that the expression of these gene products, which are thought to play an important role in cell proliferation and apoptosis in HIV- and non-HIV-associated lymphomas, are also involved in the pathogenesis of lymphomas in SIVinfected rhesus monkeys. A tentative relationship between the described gene products and the cell death indices was established for the expression of Bc12. The present primate model represents a suitable animal model for studying the pathogenesis of AIDS-associated lymphomas. <\/jats:p>","DOI":"10.1354\/vp.39-1-42","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:19:36Z","timestamp":1051215576000},"page":"42-55","source":"Crossref","is-referenced-by-count":28,"title":["SIV-associated Lymphomas in Rhesus Monkeys (<i>Macaca mulatta<\/i>) in Comparison with HIV-associated Lymphomas"],"prefix":"10.1177","volume":"39","author":[{"given":"K.","family":"Kahnt","sequence":"first","affiliation":[{"name":"German Primate Center, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"M\u00e4tz-Rensing","sequence":"additional","affiliation":[{"name":"German Primate Center, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"German Primate Center, 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