{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:53:07Z","timestamp":1787021587796,"version":"build-2736575974"},"reference-count":96,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>The aim of this study is to report 46 new cases of canine T-cell lymphomas among a series of 140 lymphomas studied by immunophenotyping (incidence 32.8%). According to the updated Kiel classification adapted to the canine species, 13 were classified as low-grade and 33 as high-grade lymphomas. Among the low-grade lymphomas, five were small clear-cell lymphomas, three were pleomorphic small-cell lymphomas, and five mycosis fungoides. Among the high-grade cases, there were 11 pleomorphic mixed-, small-, and largecell lymphomas, 6 pleomorphic large-cell lymphomas, 11 lymphoblastic lymphomas, and 5 unclassifiable highgrade plasmacytoid lymphomas. The cytohistologic features were highly suggestive of a T-cell phenotype on the basis of cell morphology (irregular nuclei and clear cytoplasms) (30\/46 cases), a T-cell zone pattern, and the presence of hyperplastic postcapillary venules (22\/46 cases). All 46 cases were CD3+ CD79a-, and among 34 cases investigated for CD4 and CD8 expression, 13 were CD4+CD8-, 13 were CD8+CD4-, and 8 were CD4CD8 double positive or double negative. The pleomorphic mixed lymphomas were mainly CD4+CD8- (6\/7) and the lymphoblastic lymphomas were double positive or double negative (6\/8). The main clinical, hematologic, and biochemical features were generalized (28\/46) or regional lymphadenopathy (16\/46), hepatosplenomegaly (15\/46), extranodal involvement (11\/46), mediastinal mass (9\/46), and leukemia (8\/46), which were mainly present in cases of lymphoblastic lymphomas and hypercalcemia (16\/46).<\/jats:p>","DOI":"10.1354\/vp.39-1-92","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T16:19:36Z","timestamp":1051201176000},"page":"92-109","source":"Crossref","is-referenced-by-count":127,"title":["Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases"],"prefix":"10.1177","volume":"39","author":[{"given":"C.","family":"Fournel-Fleury","sequence":"first","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ponce","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Felman","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Cellulaire, Centre hospitalier Lyon-Sud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Blavier","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bonnefont","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chabanne","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Marchal","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Cadore","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Goy-Thollot","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ledieu","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ghernati","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Magnol","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie-Cytologie-Immunopathologie, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"bibr1-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020205"},{"key":"bibr2-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008200307625"},{"issue":"1","key":"bibr3-vp.39-1-92","first-page":"7","volume":"6","author":"B\u00e4ckgren AW","year":"1965","journal-title":"Acta Vet Scand"},{"key":"bibr4-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.1.166.bloodjournal811166"},{"key":"bibr5-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.6.1105.1105"},{"key":"bibr6-vp.39-1-92","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.4049\/jimmunol.138.5.1502","volume":"138","author":"Brenner MB","year":"1987","journal-title":"J Immunol"},{"key":"bibr7-vp.39-1-92","first-page":"167","volume":"3","author":"Carter RF","year":"1988","journal-title":"Semin Vet Med surg (Small Anim)"},{"key":"bibr8-vp.39-1-92","first-page":"154","volume":"50","author":"Carter RF","year":"1986","journal-title":"Can J Vet Res"},{"key":"bibr9-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00401-8"},{"key":"bibr10-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1994.tb02324.x"},{"key":"bibr11-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.3.284"},{"key":"bibr12-vp.39-1-92","first-page":"529","volume":"86","author":"Chassagne-Ck\u00e9ment C","year":"1999","journal-title":"Bull Cancer"},{"key":"bibr13-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(82)50053-8"},{"key":"bibr14-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1994.tb02315.x"},{"key":"bibr15-vp.39-1-92","first-page":"1615","volume":"43","author":"Coiffier B","year":"1993","journal-title":"Rev Prat Paris"},{"key":"bibr16-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.10.1584"},{"key":"bibr17-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"bibr18-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80091-X"},{"key":"bibr19-vp.39-1-92","first-page":"1141","volume":"139","author":"Delverdier M","year":"1988","journal-title":"Rev Med Vet"},{"key":"bibr20-vp.39-1-92","volume-title":"Atlas de Cytopathologie Ganglionnaire","author":"Felman P","year":"1997"},{"key":"bibr21-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(92)90058-3"},{"key":"bibr22-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1995.tb00951.x"},{"key":"bibr23-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80065-5"},{"key":"bibr24-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80066-7"},{"key":"bibr25-vp.39-1-92","volume-title":"Atlas en Couleur de Cytologie du Cancer chez le Chien et le Chat\/Color Atlas of Cancer Cytology of the Dog and Cat","author":"Fournel-Fleury C","year":"1994"},{"key":"bibr26-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401480"},{"key":"bibr27-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-4-310"},{"key":"bibr28-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<480::AID-CNCR2820660314>3.0.CO;2-X"},{"key":"bibr29-vp.39-1-92","first-page":"356","volume":"120","author":"Grogan TM","year":"1985","journal-title":"Am J Pathol"},{"key":"bibr30-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/75.2.149"},{"key":"bibr31-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.50.809"},{"key":"bibr32-vp.39-1-92","first-page":"149","volume":"138","author":"Hamilton-Dutoit S","year":"1991","journal-title":"Am J Pathol"},{"key":"bibr33-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V"},{"key":"bibr34-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"bibr35-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(78)90111-1"},{"key":"bibr36-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.17.1226"},{"key":"bibr37-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.6.1937.1937"},{"key":"bibr38-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.6.1578.1578"},{"key":"bibr39-vp.39-1-92","first-page":"109","volume":"12","author":"Jaffe ES","year":"1999","journal-title":"Mod Pathol"},{"key":"bibr40-vp.39-1-92","volume-title":"Surgical Pathology of the Lymph Nodes and Related Organs","author":"Jaffe ES","year":"1995","edition":"2"},{"key":"bibr41-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198404000-00003"},{"key":"bibr42-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/8.suppl_2.S17"},{"key":"bibr43-vp.39-1-92","volume-title":"Peptide Immunisation as a Source of Crossspecies Reactive Antisera Recognizing Leukocyte Differentiation Antigens. Immunological Reagents for the Study of Disease in Companion Animals","author":"Jones M","year":"1993"},{"key":"bibr44-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.12.5429"},{"key":"bibr45-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400210"},{"key":"bibr46-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00093.x"},{"key":"bibr47-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1554::AID-CNCR2820500815>3.0.CO;2-Q"},{"key":"bibr48-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1354\/vp.36-4-292"},{"key":"bibr49-vp.39-1-92","first-page":"761","volume":"134","author":"Knowles DM","year":"1989","journal-title":"Am J Pathol"},{"key":"bibr50-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.1101"},{"key":"bibr51-vp.39-1-92","first-page":"870","volume":"49","author":"Ladiges WC","year":"1988","journal-title":"Am J Vet Res"},{"key":"bibr52-vp.39-1-92","volume-title":"Histologie des Lymphomes Malins Non Hodgkiniens Selon la Classification de Kiel Actualis\u00e9e","author":"Lennert K","year":"1991"},{"key":"bibr53-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81092-3"},{"key":"bibr54-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1007\/BF00046339"},{"key":"bibr55-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198104000-00009"},{"key":"bibr56-vp.39-1-92","first-page":"235","volume":"22","author":"Madewell BR","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr57-vp.39-1-92","first-page":"449","volume":"180","author":"Magnol JP","year":"1996","journal-title":"Bull Acad Natl Med"},{"key":"bibr58-vp.39-1-92","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.4049\/jimmunol.147.8.2474","volume":"147","author":"Mason DY","year":"1991","journal-title":"J Immunol"},{"key":"bibr59-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-637"},{"key":"bibr60-vp.39-1-92","first-page":"421","volume":"144","author":"Moore PF","year":"1994","journal-title":"Am J Pathol"},{"key":"bibr61-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1990.tb01831.x"},{"key":"bibr62-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01963.x"},{"key":"bibr63-vp.39-1-92","first-page":"1699","volume":"148","author":"Moore PF","year":"1996","journal-title":"Am J Pathol"},{"key":"bibr64-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.7.1078"},{"key":"bibr65-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/8.suppl_2.S49"},{"key":"bibr66-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2347::AID-CNCR2820481102>3.0.CO;2-X"},{"key":"bibr67-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"bibr68-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(80)90351-5"},{"key":"bibr69-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1975.tb05729.x"},{"key":"bibr70-vp.39-1-92","doi-asserted-by":"crossref","unstructured":"70 Parodi A, Wyers M, Paris J: Incidence of canine lymphoid leukosis. Age, sex and breed distribution: results of a necropsic survey. Proc 3rd Int Symp Comp Leukemia Res, Paris 1967, pp. 263\u2013267, Bibl Haemat 31. Karger, Basel, Switzerland\/New York, NY, 1968","DOI":"10.1159\/000391267"},{"key":"bibr71-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1988.tb00021.x"},{"key":"bibr72-vp.39-1-92","first-page":"976","volume":"152","author":"van Pelt RW","year":"1968","journal-title":"J Am Vet Med Assoc"},{"key":"bibr73-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1985.tb02082.x"},{"key":"bibr74-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008278706002"},{"key":"bibr75-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"bibr76-vp.39-1-92","first-page":"833","volume":"39","author":"Priester WA","year":"1967","journal-title":"J Natl Cancer Inst"},{"key":"bibr77-vp.39-1-92","first-page":"166","volume":"54","author":"Priester WA","year":"1980","journal-title":"Bethseda, Maryland, NC1 Monogr"},{"key":"bibr78-vp.39-1-92","first-page":"442","volume-title":"Atlas of Tumor Pathology","author":"Rappaport H","year":"1966"},{"key":"bibr79-vp.39-1-92","first-page":"265","volume":"132","author":"Salhany KE","year":"1988","journal-title":"Am J Pathol"},{"key":"bibr80-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1986.tb00308.x"},{"key":"bibr81-vp.39-1-92","volume-title":"Lymphomes, Lymphomes non Hodgkiniens-Maladie de Hodgkin","author":"Solal-Celigny Ph","year":"1997"},{"key":"bibr82-vp.39-1-92","first-page":"565","volume":"56","author":"Squire RA","year":"1973","journal-title":"J Natl Cancer Inst"},{"key":"bibr83-vp.39-1-92","first-page":"447","volume-title":"Advances in Comparative Leukemic Research","author":"Strandstrom HV","year":"1998"},{"key":"bibr84-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1994.9694451"},{"key":"bibr85-vp.39-1-92","first-page":"1179","volume":"22","author":"Teske E","year":"1994","journal-title":"Exp Haematol"},{"key":"bibr86-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"bibr87-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800901)46:5<1231::AID-CNCR2820460525>3.0.CO;2-U"},{"key":"bibr88-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.36"},{"key":"bibr89-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"bibr90-vp.39-1-92","first-page":"85","volume":"3","author":"Valli VE","year":"1988","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"bibr91-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00051-3"},{"key":"bibr92-vp.39-1-92","volume":"3","author":"Weir EC","year":"1988","journal-title":"J Bone Miner Res"},{"key":"bibr93-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"bibr94-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V61.1.192.192"},{"key":"bibr95-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01289.x"},{"key":"bibr96-vp.39-1-92","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00513.x"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.39-1-92","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.39-1-92","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.39-1-92","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:36:06Z","timestamp":1740753366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.39-1-92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1354\/vp.39-1-92"],"URL":"https:\/\/doi.org\/10.1354\/vp.39-1-92","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}