{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:41:16Z","timestamp":1789782076829,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p> The immunophenotype of tumor cells and inflammatory infiltrate associated with cutaneous melanocytic lesions (29 melanocytomas, two malignant melanomas, and 23 residual lesions) from 54 adult Iberian and Iberian X Duroc pigs were examined using a panel of nine antibodies. All neoplastic cells were vimentin<jats:sup>\u2212<\/jats:sup>, cytokeratin<jats:sup>\u2212<\/jats:sup>, and alpha-1-antitrypsin<jats:sup>\u2212<\/jats:sup> and the majority were S100<jats:sup>+<\/jats:sup>, whereas all pigmented macrophages were vimentin<jats:sup>+<\/jats:sup>, cytokeratin<jats:sup>\u2212<\/jats:sup>, and S100<jats:sup>\u2212<\/jats:sup> and most expressed alpha-1-antitrypsin. Regressing tumors were characterized by zones with low density of neoplastic cells accompanied by heavy infiltration of CD3<jats:sup>+<\/jats:sup> T lymphocytes, whereas zones with high density of neoplastic cells showed very low numbers of CD3<jats:sup>+<\/jats:sup> T lymphocytes. The infiltrate of CD79a<jats:sup>+<\/jats:sup> B cells and IgG, IgM, and IgA plasma cells was low. The majority of lymphocytes of the peri- and intratumoral infiltrate were major histocompatibility complex class II<jats:sup>+<\/jats:sup>, but neoplastic cells did not express class II antigen. The 17 residual lesions examined were composed of macrophages containing abundant melanin pigment and low to moderate numbers of CD3<jats:sup>+<\/jats:sup> T lymphocytes. The results of the present study suggest that the local cellular immune response plays a crucial role in the host response that induces regression of cutaneous melanomas and melanocytomas of the Iberian and crossbred Iberian X Duroc pigs. <\/jats:p>","DOI":"10.1354\/vp.39-4-445","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:20:28Z","timestamp":1051215628000},"page":"445-451","source":"Crossref","is-referenced-by-count":30,"title":["Immunohistochemical Characterization of Tumor Cells and Inflammatory Infiltrate Associated with Cutaneous Melanocytic Tumors of Duroc and Iberian Swine"],"prefix":"10.1177","volume":"39","author":[{"given":"J.","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Comparative Pathology, Faculty of Veterinary Medicine, Campus de Rabanales, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology, Faculty of Veterinary Medicine, Campus de Rabanales, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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