{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:55:48Z","timestamp":1793163348708,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>\n                    Fifty canine gastrointestinal (GI) mesenchymal tumors were examined to determine the occurrence of leiomyomas (LM) and GI stromal tumors and to compare their clinicopathologic features. Twenty-one tumors (42%) were histologically reclassified as gastrointestinal stromal tumors (GISTs) and 29 tumors (58%) as LMs on the basis of their histologic similarity with homologous human tumors. The GISTs occurred equally in males and females, with a mean age of 11 years (range 5\u201314 years). Five GISTs (24%) were associated with clinical signs and six (29%) had metastasis in liver or abdominal cavity. The GISTs occurred in large intestine (10, 48%), small bowel (six, 29%), stomach (four, 19%), and mesentery of small intestine (one, 5%). Histologically, they were highly cellular spindle, or less commonly epithelioid tumors with mitotic rates ranging from 0 to 19 per 10 HPF. Eleven tumors (52%) were positive for CD117 (KIT); seven (33%) were positive for smooth muscle actin but none for desmin and S-100 protein. Sequences of KIT exon 11, often mutated in human GISTs, were evaluated from four GISTs. Deletion of Try\n                    <jats:sup>556<\/jats:sup>\n                    -Lys\n                    <jats:sup>557<\/jats:sup>\n                    coexisting with duplication of Gln\n                    <jats:sup>555<\/jats:sup>\n                    in one case of GIST and T to C transition resulting in substitution of Pro for Leu\n                    <jats:sup>575<\/jats:sup>\n                    in another were identified. The LMs occurred predominantly in males (82%) with a mean age of 11 years (range 8\u201317 years). Nine tumors (31%) had associated clinical signs. They occurred in the stomach (22, 76%), esophagus (four, 14%), and intestines (three, 10%); all were paucicellular, had no mitoses, and were composed of mature smooth muscle cells. Twenty-eight (97%) were positive for smooth muscle actin and 18(62%) for desmin but none for CD117 and S-100. Both GISTs and true LMs occur in the GI tract of dogs. Both tumors have distinctive pathologic features.\n                  <\/jats:p>","DOI":"10.1354\/vp.40-1-42","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T16:21:42Z","timestamp":1051201302000},"page":"42-54","source":"Crossref","is-referenced-by-count":143,"title":["Gastrointestinal Stromal Tumors and Leiomyomas in the Dog: A Histopathologic, Immunohistochemical, and Molecular Genetic Study of 50 Cases"],"prefix":"10.1177","volume":"40","author":[{"given":"D.","family":"Frost","sequence":"first","affiliation":[{"name":"Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lasota","sequence":"additional","affiliation":[{"name":"Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miettinen","sequence":"additional","affiliation":[{"name":"Armed Forces Institute of Pathology, Washington, 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