{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:31:49Z","timestamp":1775691109268,"version":"3.50.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p> We describe the main pathologic changes in small ruminants affected by AA amyloidosis, together with the partial sequence of the protein involved. Twenty-one sheep and one goat were selected for presenting macroscopic kidney lesions compatible with systemic amyloidosis. Available tissue samples were studied by histologic, immunopathologic, and ultrastructural means. Renal lesions were characterized grossly by pale cortical surfaces with scattered, miliary, whitish-yellow foci and on cut cortical surfaces by straight, whitish-yellow striations. Gangrenous pneumonia was observed in 16 out of 21 affected sheep (76.2%), although other chronic inflammations were also observed. Amyloid was detected in all grossly affected kidneys using Congo red staining, lesions being most remarkable in glomeruli, affecting 95.5% of animals studied. Congophilic deposits were also observed in intertubular interstitium (68.2%) and medulla (57.1%). All amyloid-affected animals presented proximal convoluted tubule lesions, mostly characterized by an increase in diameter and by hyaline granular degeneration that were responsible for the macroscopic appearance of the kidney. Histologically, amyloid was also seen in blood vessels, spleen, liver, lymph nodes, gastrointestinal tract, and adrenal glands. All amyloid deposits demonstrated greenish-yellow birefringence with polarized light, and the antisera prepared against goat amyloid extracts specifically reacted with birefringent congophilic deposits of both sheep and goats. Ultrastructurally, these deposits were formed by masses of straight, nonbranching fibrils located predominantly in the basement membranes of glomerular capillaries and in the mesangium. Partial sequence of the protein in sheep and goats indicated a high degree of homology with the previously reported sequence of sheep Serum Amyloid A. <\/jats:p>","DOI":"10.1354\/vp.40-1-71","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T20:21:42Z","timestamp":1051215702000},"page":"71-80","source":"Crossref","is-referenced-by-count":40,"title":["Pathology of AA Amyloidosis in Domestic Sheep and Goats"],"prefix":"10.1177","volume":"40","author":[{"given":"C.","family":"M\u00e9nsua","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, Veterinary Faculty, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Comparative Pathology, University of C\u00f3rdoba, Veterinary Faculty, Campus de Rabanales, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Bautista","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Comparative Pathology, University of C\u00f3rdoba, Veterinary Faculty, Campus de Rabanales, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Biescas","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, Veterinary Faculty, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, Veterinary Faculty, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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