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The dog had raised creatine kinase (181 U\/liter), lactate dehydrogenase (510 U\/liter), and aspartate aminotransferase (123.6 U\/liter) levels, suggesting a muscle disease. Histochemical evaluation of muscle biopsies revealed the presence of subsarcolemmal oxidative activity, reduced nicotinamide adenine dinucleotide, and succinate dehydrogenase, and the absence of cytochrome oxidase activity. Ragged red fibers were demonstrated with Gomori trichrome stain. Ultrastructural examination of the muscle confirmed the presence of subsarcolemmal accumulations of mitochondria and morphologically atypical mitochondria. <\/jats:p>","DOI":"10.1354\/vp.40-5-507","type":"journal-article","created":{"date-parts":[[2003,9,4]],"date-time":"2003-09-04T13:32:48Z","timestamp":1062682368000},"page":"507-511","source":"Crossref","is-referenced-by-count":20,"title":["Mitochondrial Myopathy in a German Shepherd Dog"],"prefix":"10.1177","volume":"40","author":[{"given":"O.","family":"Paciello","sequence":"first","affiliation":[{"name":"Dipartimento di Patologia e Sanit\u00e0 Animale-Settore Anatomia Patologica, Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Maiolino","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Sanit\u00e0 Animale-Settore Anatomia Patologica, Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fatone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Veterinarie-Sezione di Clinica Chirurgica, Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Papparella","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Sanit\u00e0 Animale-Settore Anatomia Patologica, Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"bibr1-vp.40-5-507","first-page":"832","volume-title":"Basic Reactions of Muscle in Myology","volume":"1","author":"Batty Q","year":"1994","edition":"2"},{"issue":"5","key":"bibr2-vp.40-5-507","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2460\/javma.1992.201.05.731","volume":"201","author":"Breitschwerdt EB","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"bibr3-vp.40-5-507","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(93)90002-P"},{"key":"bibr4-vp.40-5-507","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540110075008"},{"key":"bibr5-vp.40-5-507","unstructured":"5 Ghadially NF, ed. 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