{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:53:11Z","timestamp":1787021591758,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with \u03b3\u03b4 T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver and spleen aspirates supported an antemortem diagnosis of T-cell lymphoma consistent with hepatosplenic lymphoma. The diagnosis was confirmed postmortem by a combination of routine histopathology, showing a consistent pattern of organ involvement, and immunohistochemistry showing the infiltrating neoplastic lymphocytes to be T cells expressing the \u03b3\u03b4 T-cell receptor. To our knowledge, this is the first reported case of hepatosplenic lymphoma in a dog.<\/jats:p>","DOI":"10.1354\/vp.40-5-556","type":"journal-article","created":{"date-parts":[[2003,9,4]],"date-time":"2003-09-04T09:32:48Z","timestamp":1062667968000},"page":"556-562","source":"Crossref","is-referenced-by-count":67,"title":["Hepatosplenic Lymphoma in a Dog"],"prefix":"10.1177","volume":"40","author":[{"given":"M. M.","family":"Fry","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vernau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Pesavento","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Br\u00f6mel","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"bibr1-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"bibr2-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200107000-00004"},{"key":"bibr3-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.6.461"},{"key":"bibr4-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4265.bloodjournal88114265"},{"key":"bibr5-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01952.x"},{"key":"bibr6-vp.40-5-556","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.155.1.35","volume":"155","author":"Danilenko DM","year":"1995","journal-title":"J Immunol"},{"key":"bibr7-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00893.x"},{"key":"bibr8-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.11.2213.2213"},{"key":"bibr9-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.259"},{"key":"bibr10-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1309\/TC9U-FAV7-0QBW-6DFC"},{"key":"bibr11-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00002"},{"key":"bibr12-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90179-1"},{"key":"bibr13-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-637"},{"key":"bibr14-vp.40-5-556","first-page":"77","volume-title":"Advances in Veterinary Dermatology","author":"Moore P","year":"1998"},{"key":"bibr15-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050272"},{"key":"bibr16-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00051-3"},{"key":"bibr17-vp.40-5-556","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401784"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.40-5-556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.40-5-556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.40-5-556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T09:02:12Z","timestamp":1740906132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.40-5-556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1354\/vp.40-5-556"],"URL":"https:\/\/doi.org\/10.1354\/vp.40-5-556","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}