{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:20:10Z","timestamp":1790029210506,"version":"4.0.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> Although the nephropathy of visceral leishmaniasis (VL) is known both in humans and dogs, histopathologic alterations have not been thoroughly studied. We examined renal alterations in 55 dogs with naturally acquired VL compared with five noninfected dogs from an endemic area in northeastern Brazil. Glomerulonephritis was found in 55 dogs, interstitial alterations in 53 dogs, and tubular changes in 43 dogs with VL. The glomerular alterations found were minor glomerular abnormalities ( n = 8, 14.5%), focal segmental glomerulosclerosis ( n = 10, 18.2%), mesangial proliferative glomerulonephritis ( n = 17, 32.7%), membrano-proliferative glomerulonephritis ,(n = 18, 30.9%), crescentic glomerulonephritis ( n = 1, 1.8%), and chronic glomerulonephritis ( n = 1, 1.8%). Morphometric and ultrastructural studies complemented the analysis. The five control animals exhibited no glomerular alterations. The glomerular lesions were related to functional alterations. Considering that the alterations of canine and human nephropathy in VL are very similar, the data obtained in this study constitute an important contribution to the understanding of canine and human VL nephropathy. <\/jats:p>","DOI":"10.1354\/vp.40-6-677","type":"journal-article","created":{"date-parts":[[2003,11,7]],"date-time":"2003-11-07T21:58:03Z","timestamp":1068242283000},"page":"677-684","source":"Crossref","is-referenced-by-count":106,"title":["Histopathologic Patterns of Nephropathy in Naturally Acquired Canine Visceral Leishmaniasis"],"prefix":"10.1177","volume":"40","author":[{"given":"F. A. L.","family":"Costa","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Soroepidemiologia e Imunobiologia Celular e Molecular, Instituto de Medicina Tropical de S\u00e3o Paulo, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Centro de Ci\u011bncias Agr\u00e1rias, Universidade Federal do Piau\u00ed, Teresina, Piau\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Goto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Soroepidemiologia e Imunobiologia Celular e Molecular, Instituto de Medicina Tropical de S\u00e3o Paulo, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C. B.","family":"Saldanha","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Centro de Ci\u011bncias Agr\u00e1rias, Universidade Federal do Piau\u00ed, Teresina, Piau\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. L.","family":"Sinhorini","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"bibr1-vp.40-6-677","unstructured":"1 Alencar JE: Calazar canino. Contribui\u00e7\u00e3o para o estudo da epidemiologia do calazar no Brasil. In: Doctoral Thesis, Universidade Federal do Cear\u00e1, p. 342. 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