{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:26:32Z","timestamp":1784831192418,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p> Alveolar echinococcosis was diagnosed in 12 cynomolgus monkeys ( Macaca fascicularis) at postmortem examination within a period of 6 years. Besides consistent involvement of the liver, parasitic lesions were also present in mesenteric lymph nodes, pancreas, lung, and kidney. In the liver, various patterns of host's responses to parasitic tissue could be distinguished. Infiltration of macrophages, often multinucleated, around usually intact metacestodes was the main feature of one pattern. A second pattern was characterized by the presence of abundant, normally degenerate granulocytes in addition to macrophages surrounding collapsed laminated structures. Finally and as a third pattern, some cysts were surrounded by marked collagen deposition, which was usually not a significant feature of the other foci. Parasitic cysts with protoscolices were observed in foci with the first and third pattern but not in the second one. The simultaneous occurrence of all three patterns was observed in most animals. Type AA amyloid was identified either in the space of Diss\u00e9, macro-phages or blood vessel walls in nine animals using immunohistochemistry. Identity of parasitic structures such as metacestodes of Echinococcus multilocularis was confirmed immunohistochemically. All animals that could be tested serologically (7\/12) had detectable antibodies against the E. multilocularis-specific Em2 antigen. Liver lesions of six animals were additionally analyzed by polymerase chain reaction, yielding the amplification of a specific E. multilocularis DNA fragment in each case. <\/jats:p>","DOI":"10.1354\/vp.41-3-229","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T21:47:47Z","timestamp":1083966467000},"page":"229-234","source":"Crossref","is-referenced-by-count":31,"title":["Hepatic Alveolar Echinococcosis in Cynomolgus Monkeys (<i>Macaca fascicularis<\/i>)"],"prefix":"10.1177","volume":"41","author":[{"given":"L. N.","family":"Bacciarini","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Abteilung f\u00fcr Fisch- und Wildtiermedizin, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Parasitologie, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Pagan","sequence":"additional","affiliation":[{"name":"Zoologischer Garten Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rehmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Abteilung f\u00fcr Fisch- und Wildtiermedizin, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gr\u00f6ne","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Abteilung f\u00fcr Fisch- und Wildtiermedizin, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,5,1]]},"reference":[{"key":"bibr1-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1987.11812136"},{"key":"bibr2-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1007\/BF00926565"},{"key":"bibr3-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1983.11811742"},{"key":"bibr4-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90166-5"},{"key":"bibr5-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-381.x"},{"key":"bibr6-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00424-1"},{"key":"bibr7-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000059278"},{"key":"bibr8-vp.41-3-229","doi-asserted-by":"publisher","DOI":"10.1159\/000333544"},{"key":"bibr9-vp.41-3-229","unstructured":"9 Eckert J, Gemmell MA, Meslin FX, Pawlowski ZS: WHO\/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern, 2nd ed., p. 54. 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