{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:48:32Z","timestamp":1793299712530,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p> A Chlamydophila abortus-induced abortion model was carried out on the basis of the experimental infection of ewes at day 75 of gestation. The infection induced abortions and the birth of weak lambs during the last 3 weeks of pregnancy. To study the kinetics of the infection in the placenta and in other organs, infected ewes were killed at 105, 120, and 130 days of gestation and also several days after abortion or parturition. Infected ewes developed a systemic infection that caused a mild and transient pneumonia and focal hepatitis. Pathologic changes were observed in placentas at 120 day of gestation, although the lesions varied between animals and even between placentomes of the same placenta. The first placental area infected was the maternal stroma and epithelium next to the intercaruncular areas, where neutrophilic response seemed to control the infection. A substantial degree of multiplication of C. abortus was then observed in the trophoblast cells of the placentome, periplacentomal choriallantoic membranes, and hilius, with an inflammatory exudate composed mainly of neutrophils, some macrophages, and very scarce lymphocytes. After abortion, the lesions affected the intercotyledonary areas of the aborted placentas, whereas in the uterus significant lymphocyte infiltration was observed, together with a rapid decrease of the C. abortus antigen in the degenerated caruncular tissues. <\/jats:p>","DOI":"10.1354\/vp.41-5-498","type":"journal-article","created":{"date-parts":[[2004,9,6]],"date-time":"2004-09-06T23:54:40Z","timestamp":1094514880000},"page":"498-505","source":"Crossref","is-referenced-by-count":41,"title":["Kinetics of Infection and Effects on the Placenta of <i>Clamydophila abortus<\/i> in Experimentally Infected Pregnant Ewes"],"prefix":"10.1177","volume":"41","author":[{"given":"J. A.","family":"Navarro","sequence":"first","affiliation":[{"name":"Departmento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas, Universidad de Murcia, Murcia, Spain; and Departmento de Patolog\u00eda Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Garc\u00eda de la Fuente","sequence":"additional","affiliation":[{"name":"Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain; and Departmento de Patolog\u00eda Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departmento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas, Universidad de Murcia, Murcia, Spain; and Departmento de Patolog\u00eda Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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