{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:49:07Z","timestamp":1768290547417,"version":"3.49.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p> This study evaluated bacterial skeletal disease in conjunction with the major histocompatibility complex (MHC) in a genetically pure line of broiler breeder chickens. Chickens from six broiler breeder flocks were examined for skeletal lesions, bacterial pathogens, and MHC genotype. During a 10-week period, eighty-eight, 9- to 21-week-old lame chickens and 34 normal, age-matched controls were selected. Tenosynovitis, arthritis, and femoral or tibiotarsal (or both) osteomyelitis occurred in 86 of 88 (97.7%) lame chickens. Ninety-five bacterial isolates were obtained from 83 of 88 (94.3%) lame birds and 4 of 34 (11.8%) controls. Staphylococcus spp. was isolated from 72.6% of the skeletal lesions, predominantly Staphylococcus aureus (38.9%). MHC B complex genotypes were determined by hemagglutination for 88 lame birds, 34 controls, and 200 randomly selected birds from each of the six flocks (1,200 total). Combined chi-square analysis revealed that the homozygous MHC genotypes B<jats:sup>A4\/A4<\/jats:sup> (x<jats:sup>2<\/jats:sup> = 14.54, P = 0.0063) and B<jats:sup>A12\/A12<\/jats:sup> (x<jats:sup>2<\/jats:sup> = 42.77, P = 0.0001) were overrepresented in the sample of symptomatic birds compared with random samples from the same flocks. The homozygous A4 and A12 MHC genotypes influenced flock chi-square values more than the corresponding heterozygotes. An MHC B complex influence on bacterial skeletal disease was apparent in this line of broiler breeders. <\/jats:p>","DOI":"10.1354\/vp.42-3-275","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T01:58:27Z","timestamp":1115258307000},"page":"275-281","source":"Crossref","is-referenced-by-count":28,"title":["The Avian Major Histocompatibility Complex Influences Bacterial Skeletal Disease in Broiler Breeder Chickens"],"prefix":"10.1177","volume":"42","author":[{"given":"K. S.","family":"Joiner","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Hoerr","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Agronomy and Soils, College of Agriculture, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Ewald","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL"},{"name":"Department of Poultry Science, College of Agriculture, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"bibr1-vp.42-3-275","first-page":"347","volume-title":"International Symposium on Marek's Disease","author":"Abplanalp H","year":"1984"},{"key":"bibr2-vp.42-3-275","first-page":"798","volume-title":"Diseases of Poultry","author":"Andreasen CB","year":"2003","edition":"11"},{"key":"bibr3-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823560"},{"key":"bibr4-vp.42-3-275","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/genetics\/35.6.633","volume":"35","author":"Briles WE","year":"1950","journal-title":"Genetics"},{"key":"bibr5-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.2.555"},{"key":"bibr6-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0711873"},{"key":"bibr7-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.12.1846"},{"key":"bibr8-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0660203"},{"key":"bibr9-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00191-3"},{"key":"bibr10-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1993.tb00312.x"},{"key":"bibr11-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.2307\/1591096"},{"key":"bibr12-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0650241"},{"key":"bibr13-vp.42-3-275","first-page":"35","volume-title":"The Major Histocompatibility Complex in Domestic Animal Species","author":"Kaufman JF","year":"1996"},{"key":"bibr14-vp.42-3-275","first-page":"129","volume":"212","author":"Kaufman JF","year":"1996","journal-title":"Curr Top Microbiol Immunol"},{"key":"bibr15-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1136\/vr.131.9.190"},{"key":"bibr16-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/78.8.1085"},{"key":"bibr17-vp.42-3-275","first-page":"185","volume-title":"Manipulation of the Avian Genome","author":"Lamont SJ","year":"1993"},{"key":"bibr18-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.8.1111"},{"key":"bibr19-vp.42-3-275","first-page":"497","volume-title":"Poultry Breeding and Genetics","author":"Lamont SJ","year":"1990"},{"key":"bibr20-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050482"},{"key":"bibr21-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1080\/03079459995019"},{"key":"bibr22-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1080\/03079450050118386"},{"key":"bibr23-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/78.8.1191"},{"key":"bibr24-vp.42-3-275","first-page":"47","volume":"12","author":"Plachy J","year":"1992","journal-title":"Crit Rev Immunol"},{"key":"bibr25-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1991.10.663"},{"key":"bibr26-vp.42-3-275","first-page":"101","volume-title":"Avian Immunology: Basis and Practice","author":"Schat KA","year":"1987"},{"key":"bibr27-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(94)90148-1"},{"key":"bibr28-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-5-519"},{"key":"bibr29-vp.42-3-275","doi-asserted-by":"publisher","DOI":"10.1007\/BF00387856"},{"key":"bibr30-vp.42-3-275","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.4049\/jimmunol.140.9.2864","volume":"140","author":"Vainio O","year":"1988","journal-title":"J Immunol"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.42-3-275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.42-3-275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.42-3-275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:23:07Z","timestamp":1740784987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.42-3-275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1354\/vp.42-3-275"],"URL":"https:\/\/doi.org\/10.1354\/vp.42-3-275","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}