{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:50:33Z","timestamp":1789951833993,"version":"4.0.1"},"reference-count":72,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n                    Clinicopathologic and immunophenotypic characteristics of large granular lymphocyte (LGL) neoplasia in 21 cats were examined. All cats were domestic short (19) or long hair (2) with a mean age of 9.3 years at diagnosis. Increased peripheral blood LGL counts were present in 18\/21 cats. Neutrophilia (12\/21 cats) and increased serum liver enzymes (7\/12), total and direct bilirubin (7\/13), BUN (5\/14), and creatinine (2\/14) were observed. Cats usually presented with advanced disease and none survived longer than 84 days (mean 18.8 days) postdiagnosis. Cytologically, LGLs had a mature (6\/21), immature (13\/21), or mixed (2\/21) morphology. Necropsy lesions consisted of neoplastic lymphoid infiltrates in the jejunum, ileum, and duodenum in decreasing order of frequency. In the small intestine, mucosal ulceration (9\/13) and epitheliotropism of neoplastic cells (9\/13) were common. Neoplastic infiltrates were also present in the mesenteric lymph nodes (13\/13), liver (12\/13), spleen (8\/13), kidneys (5\/ 7), and bone marrow (5\/7). A T cell phenotype (CD3\n                    <jats:sub>\u220a+<\/jats:sub>\n                    ) characterized LGL neoplasia in 19\/21 cases. A CD8\u03b1\u03b1+ cytotoxic\/suppressor phenotype was present in 12\/19 T cell tumors, 2 had a CD4+CD8\u03b1\u03b1 phenotype, 3 had a CD4-CD8- phenotype, and 2 were CD4+ helper T cells. CD8\u03b2 chain expression was not detected in any instance. In two cats, a B or T cell origin could not be established. CD103 was expressed by 11 of 19 (58%) of the lymphomas tested. The immunophenotypic features shared by neoplastic LGLs in the cat and feline intestinal intraepithelial lymphocytes (IELs) support a small intestinal IEL origin for feline LGL lymphoma.\n                  <\/jats:p>","DOI":"10.1354\/vp.43-1-15","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T15:27:45Z","timestamp":1136993265000},"page":"15-28","source":"Crossref","is-referenced-by-count":82,"title":["Feline Large Granular Lymphocyte (LGL) Lymphoma with Secondary Leukemia: Primary Intestinal Origin with Predominance of a CD3\/CD8\u03b1\u03b1 Phenotype"],"prefix":"10.1177","volume":"43","author":[{"given":"P.","family":"Roccabianca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vernau","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Animale (PR, MC), Igiene e Sanit\u00e0 Pubblica Veterinaria\u2013Sezione di Anatomia Patologica e Patologia Aviare Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Milano, Italy; and Department of Pathology, Microbiology and Immunology (WV, PFM), School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caniatti","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Animale (PR, MC), Igiene e Sanit\u00e0 Pubblica Veterinaria\u2013Sezione di Anatomia Patologica e Patologia Aviare Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Milano, Italy; and Department of Pathology, Microbiology and Immunology (WV, PFM), School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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