{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T19:47:02Z","timestamp":1767642422878,"version":"3.48.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Central core disease is a nonprogressive or slowly progressive congenital myopathy with a variable degree of hypotonia and axial and proximal muscle weakness that is histologically characterized by areas devoid of oxidative enzyme activity, resulting from an absence or low numbers of mitochondria in these regions (central core). A 10-month-old, male, pony foal was examined because of stiff gait, marked contractures of the distal portion of the limbs, flexion deformities of the hooves, and moderate hypotonia that had been present from birth. The foal had increased creatine kinase (282 U\/ liter; reference interval 10-135 U\/liter), lactate dehydrogenase (1,188 U\/liter; reference interval 150\u2013450 U\/liter), and aspartate transaminase (377 U\/liter; reference interval &lt;290 U\/liter) activities, suggesting muscle disease. Muscle biopsy was performed. In cytochrome oxidase-, succinate dehydrogenase-, and reduced nicotinamide adenine dinucleotide tetrazolium reductase-reacted sections, the dominant morphologic feature was the absence of oxidative enzyme activity in the cores. By use of immunohistochemical technique with a monoclonal antibody against desmin, the cores were clearly delineated and a desmin network was present within the cores. Ultrastructurally, the core areas were characterized by preserved sarcomeres with irregular Z-lines, with some streaming or zigzag appearance and abnormal sarcoplasmic reticulum profiles and T-tubules. Lack of mitochrondria within central cores was observed. Diagnosis of myopathy with central cores was made.<\/jats:p>","DOI":"10.1354\/vp.43-4-579","type":"journal-article","created":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T18:10:38Z","timestamp":1152900638000},"page":"579-583","source":"Crossref","is-referenced-by-count":3,"title":["Myopathy with Central Cores in a Foal"],"prefix":"10.1177","volume":"43","author":[{"given":"O.","family":"Paciello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Pasolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Navas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Papparella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,7]]},"reference":[{"key":"e_1_3_2_2_1","volume-title":"Muscle Biopsy: A Modern Approach","author":"Dubowitz V","year":"1973","unstructured":"1 Dubowitz V, Brooke MH: Muscle Biopsy: A Modern Approach. The Lavenham Press Ltd, Lavenham, Suffolk, England, 1973"},{"key":"e_1_3_2_3_1","first-page":"1487","volume-title":"Congenital Myopathies in Myology","author":"Fardeau M","year":"1994","unstructured":"2 Fardeau M, Tom\u00e8 FMS: Congenital Myopathies in Myology, 2nd ed., vol. 2, chap 57, pp. 1487\u20131532. McGraw-Hill, New York, NY, 1994","edition":"2"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10231"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588302000104"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120203"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(02)00136-8"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90461-M"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(98)00064-9"},{"key":"e_1_3_2_10_1","first-page":"513","article-title":"A congenital progressive ovine muscular dystrophy","volume":"6","author":"McGavin MD","year":"1969","unstructured":"9 McGavin MD, Baynes I: A congenital progressive ovine muscular dystrophy. Vet Pathol 6:513\u2013524,1969","journal-title":"Vet Pathol"},{"key":"e_1_3_2_11_1","first-page":"398","article-title":"Refined genetic localization for central core disease","volume":"52","author":"Mulley JC","year":"1993","unstructured":"10 Mulley JC, Kozman HM, Phillips HA, Gedeon AK, McCure JA, Iles DE, Gregg RG, Hogan K, Couch FJ, MacLennan DH: Refined genetic localization for central core disease. Am J Hum Genet 52:398\u2013405, 1993","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(87)90010-7"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4626"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg244"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00135-9"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90013-2"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.43-4-579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1354\/vp.43-4-579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1354\/vp.43-4-579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:33:14Z","timestamp":1767630794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1354\/vp.43-4-579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1354\/vp.43-4-579"],"URL":"https:\/\/doi.org\/10.1354\/vp.43-4-579","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"type":"print","value":"0300-9858"},{"type":"electronic","value":"1544-2217"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}