{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:52:47Z","timestamp":1740981167335,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p> We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and limb malformation. <\/jats:p>","DOI":"10.1354\/vp.43-5-789","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T18:43:53Z","timestamp":1158000233000},"page":"789-792","source":"Crossref","is-referenced-by-count":6,"title":["Chromosome Instability in a Calf with Amelia of Thoracic Limbs"],"prefix":"10.1177","volume":"43","author":[{"given":"I.","family":"Szczerbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stefaniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dubiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Siembieda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Nizanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Switonski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr1-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1159\/000072843"},{"key":"bibr2-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199704000-00001"},{"key":"bibr3-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/67410\/2004"},{"key":"bibr4-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1136\/vr.112.18.429"},{"key":"bibr5-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10776"},{"key":"bibr6-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991029)86:5<497::AID-AJMG18>3.0.CO;2-X"},{"key":"bibr7-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10781"},{"key":"bibr8-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.10.879"},{"key":"bibr9-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geh041"},{"key":"bibr10-vp.43-5-789","first-page":"283","volume":"92","author":"International System for Chromosome Nomenclature of Domestic Bovids (ISCNB","year":"2000","journal-title":"Cytogenet Cell Genet"},{"key":"bibr11-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-5-508"},{"key":"bibr12-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01823-5"},{"key":"bibr13-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350118"},{"key":"bibr14-vp.43-5-789","doi-asserted-by":"publisher","DOI":"10.1086\/382196"},{"key":"bibr15-vp.43-5-789","doi-asserted-by":"crossref","unstructured":"15 Nowacka J, Urbaniak K, Antosik P, Jaskowski JM, Frackowiak H, Switonski M: Polymelia associated with frequent chromosome break in a heifer. 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