{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:25:45Z","timestamp":1777605945569,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                    Spontaneous and experimental poisoning with the swainsonine-containing and calystegine-containing plant\n                    <jats:italic toggle=\"yes\">Ipomoea carnea<\/jats:italic>\n                    subsp\n                    <jats:italic toggle=\"yes\">fistulosa<\/jats:italic>\n                    is described. Three of 8 goats presenting with emaciation, weakness, symmetrical ataxia, posterior paresis, proprioceptive deficits, abnormal posture, abnormal postural reaction, and muscle hypertonia were necropsied.\n                    <jats:italic toggle=\"yes\">I fistulosa<\/jats:italic>\n                    was suspected to be the cause of the neurologic disease in all cases. An experiment was conducted to confirm the diagnosis using 12 goats and diets containing 3 different concentrations of the plant. All goats fed\n                    <jats:italic toggle=\"yes\">I fistulosa<\/jats:italic>\n                    developed neurological signs that were similar to those observed in the spontaneous intoxication. Muscle atrophy and pallor were the only macroscopic changes observed in spontaneous and in experimental intoxication. Histological lesions of spontaneous and experimental animals were similar. The most prominent lesion was cytoplasmic vacuolation in neurons of the central and the autonomous nervous system, pancreatic acinar cells, hepatocytes, Kupffer cells, follicular epithelial cells of the thyroid gland, and macrophages of the lymphatic tissues. Neuronal necrosis, axonal spheroids formation, and astrogliosis were additionally observed in the brain. Ultrastructurally, the cytoplasmic vacuoles consisted of distended lysosomes surrounded by a single-layered membrane. Nonreduced end-rests or sequence of \u03b1-Man, \u03b1-Glc, \u03b2(1\u20134)-GlcNAc, and NeuNAc on lysosomal membrane were revealed by lectin histochemistry. Samples of plants used in the experimental trial contained swainsonine and calystegine and their intermediary derivate. We conclude that\n                    <jats:italic toggle=\"yes\">I fistulosa<\/jats:italic>\n                    induces a glycoprotein storage disease primarily based on the inhibition of the lysosomal \u03b1-mannosidase by the alkaloid swainsonine.\n                  <\/jats:p>","DOI":"10.1354\/vp.44-2-170","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T17:13:38Z","timestamp":1172164418000},"page":"170-184","source":"Crossref","is-referenced-by-count":72,"title":["Spontaneous and Experimental Glycoprotein Storage Disease of Goats Induced by\n                    <i>Ipomoea carnea<\/i>\n                    subsp\n                    <i>fistulosa<\/i>\n                    (Convolvulaceae)"],"prefix":"10.1177","volume":"44","author":[{"given":"A. G.","family":"Armi\u00e9n","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Justus-Liebig-Universi\u00e4t Giessen, Giessen, Germany (AGA, KF)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Tokarnia","sequence":"additional","affiliation":[{"name":"Departamento de Nutri\u00e7\u00e3o Animal e Pastagem, Instituto de Zootecnia, Universidade Federal Rural do Rio de Janeiro, Brazil (CRT, PVP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Vargas","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Departamento de Nutri\u00e7\u00e3o Animal e Pastagem, Instituto de Zootecnia, Universidade Federal Rural do Rio de Janeiro, Brazil (CRT, PVP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Frese","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Justus-Liebig-Universi\u00e4t Giessen, Giessen, Germany (AGA, KF)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,3]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(73)90011-X"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1310155"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200403"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/32.12.6501863"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/34.4.3081625"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/1222581"},{"issue":"1","key":"e_1_3_2_8_1","first-page":"1","article-title":"Solanum fastigiatum var. fastigiatum and Solanum subsp. poisoning in cattle: ultrastructural changes in the cerebellum","volume":"7","author":"Barros SS","year":"1987","unstructured":"7 Barros SS, Riet-Correia F, Andujar MB, Motta A, Schild AL: Solanum fastigiatum var. fastigiatum and Solanum subsp. poisoning in cattle: ultrastructural changes in the cerebellum. 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