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By histology, there were variably stained storage cytosomes within neurons, including many that stained for gangliosides. On ultrastructure examination, these cytosomes contained either moderately dense granular material, tentatively interpreted as precipitated glycosaminoglycan; a variety of multilaminar bodies, interpreted as being associated with secondary accumulation of gangliosides; or a mixture of both types. In the liver, storage vesicles also contained excess glycogen as a secondary storage product. In various tissues, there were large foamy macrophages. In the brain, many of these were in juxtaposition with neurons, and, on ultrastructure examination, they contained storage cytosomes similar to those in neurons. However, the neuron in association with such a macrophage frequently showed little such material. <\/jats:p>","DOI":"10.1354\/vp.44-5-569","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T19:28:03Z","timestamp":1189452483000},"page":"569-578","source":"Crossref","is-referenced-by-count":26,"title":["Pathology of Mucopolysaccharidosis IIIA in Huntaway Dogs"],"prefix":"10.1177","volume":"44","author":[{"given":"R. D.","family":"Jolly","sequence":"first","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand (RDJ, ACJ, EJN)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand (RDJ, ACJ, EJN)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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