{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:34:13Z","timestamp":1790973253784,"version":"4.1.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>During fibrosis, the extracellular matrix (ECM) is continuously remodeled and increases in volume due to the production of various proteins. We studied the distribution of tenascin-C (TN-C) and the correlation of TN-C with the necro-inflammatory activity and expression of alpha\u2013smooth muscle actin (\u03b1-SMA), cytokeratin 7 (CK7), and CD3+ T-lymphocytes in canine chronic hepatitis. This was analyzed using immunohistochemistry and semiquantitative scoring. We used 3 groups ( n = 19) of dogs: group 1 ( n = 5) with neonatal hepatitis\/lobular dissecting hepatitis (NH\/LDH), group 2 ( n = 8) with chronic hepatitis\/cirrhosis (CH\/CIRR), and group 3 ( n = 6) consisting of healthy animals. In normal livers, TN-C was localized in Disse's space and around bile ducts and blood vessels. In CH\/CIRR livers, TN-C was localized at the periphery of the regenerating nodules and was conspicuous in the bridging fibrous bands. In NH\/LDH, TN-C was diffusely distributed along the reticular fibers that dissected between single cells or groups of hepatocytes. \u03b1-SMA in the normal hepatic parenchyma showed an irregular distribution along the perisinusoidal linings. In other groups, \u03b1-SMA was increased in fibrotic septa and perisinusoidal linings. In normal livers, CK7 was positive in bile ducts. In other groups, CK7-expressing cells were conspicuous in the portal-parenchymal interface, the periphery of the regenerative nodules, and the degenerated parenchyma. The pattern of CD3+ lymphocytes was inversely proportional to that of TN-C. These results also showed that TN-C is strongly correlated with increased fibrotic stage, inflammatory activity, and expression of CK7 and \u03b1-SMA. TN-C, CK7, and CD3 expression did not differ between diagnostic groups.<\/jats:p>","DOI":"10.1354\/vp.44-6-803","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T13:25:07Z","timestamp":1196083507000},"page":"803-813","source":"Crossref","is-referenced-by-count":27,"title":["Tenascin-C in Chronic Canine Hepatitis: Immunohistochemical Localization and Correlation with Necro-Inflammatory Activity, Fibrotic Stage, and Expression of Alpha-Smooth Muscle Actin, Cytokeratin 7, and CD3+ Cells"],"prefix":"10.1177","volume":"44","author":[{"given":"G. 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