{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:53:10Z","timestamp":1785577990981,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p> A high prevalence of systemic amyloidosis was documented in the black-footed cat ( Felis nigripes) based on a retrospective review of necropsy tissues ( n = 38) submitted as part of ongoing disease surveillance. Some degree of amyloid deposition was present in 33 of 38 (87%) of the examined cats, and amyloidosis was the most common cause of death (26\/38, 68%). Amyloid deposition was most severe in the renal medullary interstitium (30\/33, 91%) and glomeruli (21\/33, 63%). Other common sites included the splenic follicular germinal centers (26\/31, 84%), gastric lamina propria (9\/23, 39%), and intestinal lamina propria (3\/23, 13%). Amyloid in all sites stained with Congo red, and in 13 of 15 (87%) cats, deposits had strong immunoreactivity for canine AA protein by immunohistochemistry. There was no association with concurrent chronic inflammatory conditions ( P = .51), suggesting that amyloidosis was not secondary to inflammation. Adrenal cortical hyperplasia, a morphologic indicator of stress that can predispose to amyloid deposition, was similarly not associated ( P = .09) with amyloidosis. However, adrenals were not available from the majority of cats without amyloidosis; therefore, further analysis of this risk factor is warranted. Heritability estimation suggested that amyloidosis might be familial in this species. Additionally, tissues from a single free-ranging black-footed cat had small amounts of amyloid deposition, suggesting that there could be a predilection for amyloidosis in this species. Research to identify the protein sequence of serum amyloid A (SAA) in the black-footed cat is needed to further investigate the possibility of an amyloidogenic SAA in this species. <\/jats:p>","DOI":"10.1354\/vp.45-3-393","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T18:48:41Z","timestamp":1210963721000},"page":"393-400","source":"Crossref","is-referenced-by-count":41,"title":["Amyloidosis in Black-footed Cats (<i>Felis nigripes<\/i>)"],"prefix":"10.1177","volume":"45","author":[{"given":"K. 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