{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T19:40:07Z","timestamp":1741030807309,"version":"3.38.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p> The role of subgroup J avian leukosis virus (ALV J) infection profile in the development of histiocytic sarcomatosis (HS) in chickens was evaluated using retrospective analysis of 2 experiments involving in ovo and at-hatch inoculation of commercial meat-type and ADOL line 0 chickens with 100 or 10,000 TCID<jats:sub>50<\/jats:sub> of various strains ALV J. HS was observed only in persistently viremic, meat-type chickens that were inoculated at hatch, but not in immunotolerized (persistently viremic, with no antibodies), in ovo inoculated chickens. However, the immunotolerized, in ovo inoculated chickens developed a high incidence of myeloid tumors. HS appeared to arise from the splenic ellipsoids and red pulp, and metastasized to liver, kidney, and other organs. The neoplastic cells were diffusely positive for ChL5, CD45, and MHC class II with multifocal infiltration of T and B lymphocytes. Expression of viral antigen gp85 within HS was very low compared with that noted in ALV J-induced myelocytomas. The above observations suggest that the mechanisms of oncogenesis of HS might be different from that of other ALV J-induced tumors. <\/jats:p>","DOI":"10.1354\/vp.46-2-282","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T09:03:55Z","timestamp":1236157435000},"page":"282-287","source":"Crossref","is-referenced-by-count":6,"title":["Subgroup J Avian Leukosis Virus-Induced Histiocytic Sarcomatosis Occurs                Only in Persistently Viremic but Not Immunotolerized Meat-type                Chickens"],"prefix":"10.1177","volume":"46","author":[{"given":"A. R.","family":"Pandiri","sequence":"first","affiliation":[{"name":"USDA ARS Avian Disease and Oncology Laboratory, East Lansing, MI;"},{"name":"Department of Pathobiology and Diagnostic Investigation, Michigan State\r            University, Lansing, MI;"},{"name":"Department of Population Health and Pathobiology, North Carolina State\r            University, Raleigh, NC;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Gimeno","sequence":"additional","affiliation":[{"name":"USDA ARS Avian Disease and Oncology Laboratory, East Lansing, MI;"},{"name":"Department of Population Health and Pathobiology, North Carolina State\r            University, Raleigh, NC;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, Michigan State\r            University, Lansing, MI;"},{"name":"College of Veterinary Medicine, Purdue University, West Lafayette,\r            IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, Michigan State\r            University, Lansing, MI;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Fadly","sequence":"additional","affiliation":[{"name":"USDA ARS Avian Disease and Oncology Laboratory, East Lansing, MI;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"doi-asserted-by":"publisher","key":"bibr1-vp.46-2-282","DOI":"10.2307\/1592351"},{"doi-asserted-by":"publisher","key":"bibr2-vp.46-2-282","DOI":"10.1128\/JVI.64.12.6054-6062.1990"},{"key":"bibr3-vp.46-2-282","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.4049\/jimmunol.140.7.2133","volume":"140","author":"Chan ML","year":"1988","journal-title":"J Immunol"},{"doi-asserted-by":"publisher","key":"bibr4-vp.46-2-282","DOI":"10.1084\/jem.164.1.375"},{"key":"bibr5-vp.46-2-282","first-page":"137","volume-title":"Avian Immunology, Basis and Practice","author":"Chen CLH","year":"1987"},{"doi-asserted-by":"publisher","key":"bibr6-vp.46-2-282","DOI":"10.1016\/0165-2427(91)90119-W"},{"key":"bibr7-vp.46-2-282","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.4049\/jimmunol.132.5.2524","volume":"132","author":"Ewert DL","year":"1984","journal-title":"J Immunol"},{"doi-asserted-by":"publisher","key":"bibr8-vp.46-2-282","DOI":"10.2307\/1592636"},{"doi-asserted-by":"publisher","key":"bibr9-vp.46-2-282","DOI":"10.1080\/03079459994768"},{"doi-asserted-by":"publisher","key":"bibr10-vp.46-2-282","DOI":"10.2307\/1592390"},{"doi-asserted-by":"publisher","key":"bibr11-vp.46-2-282","DOI":"10.1038\/290475a0"},{"unstructured":"12 Lupiani B, Pandiri A, Mays J, Conklin K, Silva RF, Reed WM, Fadly AM: Pathogenicity of a molecular clone of a field strain of                   subgroup J Avian Leukosis Virus. 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